Science
Mechanism of Action
The extract exerts its anti-inflammatory effects by modulating the Nuclear Factor-κB (NF-κB) pathway. It significantly reduces lipopolysaccharide (LPS)-induced levels of pro-inflammatory mediators such as nitric oxide (NO), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and IL-6. This modulation involves the downregulation of inducible NO synthase and pro-inflammatory cytokine mRNA expression, along with inhibiting the intranuclear translocation of NF-κB p65 and reducing IκBα phosphorylation. Additionally, it functions as an antioxidant by inhibiting oxygen-promoted reactions, thereby preventing cellular damage. As a humectant, its smaller molecular components help attract and retain moisture within the skin, supporting skin conditioning and protection.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 Demonstrated anti-inflammatory effects in murine macrophages, decreasing LPS-induced levels of NO, TNF-α, IL-1β, and IL-6. Cell viability remained above 99% at concentrations from 0.5 mg/mL to 1.5 mg/mL.
Transparency
Dusting Analysis
Data regarding 'dusting' or potential for minimal effective concentrations to be diluted for marketing purposes is not available in the provided research.
The Formula
Formulation
Stability
While a specific optimal pH range for stability is not detailed, as a hydrolyzed plant extract, its solubility and potential stability may be pH-dependent. Similar protein hydrolysates often exhibit variable solubility, with some demonstrating reduced solubility in acidic conditions (pH 2.0-4.0) due to their isoelectric point.
Safety
Safety Profile
No specific safety assessments from CIR, SCCS, or FDA were found for this hydrolyzed extract. Comprehensive safety profiles were not available in consulted databases, leading to an 'unknown' sensitization risk.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This hydrolyzed extract is valuable for its potential to provide anti-inflammatory and antioxidant benefits, coupled with humectant properties, making it suitable for a wide range of skin types, particularly those seeking soothing and protective care, though further in vivo human studies and safety assessments would provide greater precision.
Related
Similar Ingredients
Finding similar ingredients…
References
Sources