Science
Mechanism of Action
This extract functions as a robust antioxidant by directly scavenging free radicals and elevating endogenous antioxidant enzyme activity, thereby shielding cells from oxidative damage. Its anti-inflammatory effects are mediated by reducing the expression of key inflammatory markers, including TNF-α, IL-6, and IL-1β, through the inhibition of the JNK signaling pathway. For skin, it improves tone and compactness, exhibits an astringent quality, and demonstrates anti-melanogenic and cytoprotective actions in melanocytes. This involves decreasing melanin production via the inhibition of melanogenesis-associated proteins (MITF, tyrosinase, and TRP2) through MAPK/JNK phosphorylation, while also protecting cells from oxidative stress by inducing autophagy and MITF expression. Additionally, it acts as a humectant.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 Codonopsis pilosula extract (CPE) at 1 mg/ml demonstrated a 30% reduction in protein oxidation and a 16-fold increase in reducing power.
- 02 It significantly inhibited LPS-induced production of iNOS by 60%, suggesting effective suppression of NO production.
- 03 Codonopsis pilosula compounds exhibited broad therapeutic effects, including antioxidant and immunomodulatory activities, with IC50 values ranging from 10-50 µg/mL.
Transparency
Dusting Analysis
There is no data to suggest that this ingredient is commonly dusted or has specific dusting thresholds.
The Formula
Formulation
Stability
If supplied in powder form, Codonopsis extract powders are prone to hygroscopy, meaning they easily absorb atmospheric moisture, which may lead to clumping if not stored in dry, sealed packaging.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) has not formally assessed HYDROLYZED CODONOPSIS PILOSULA ROOT EXTRACT. However, its non-hydrolyzed form, Codonopsis pilosula extract powder, was recognized as safe for dietary supplement use in the U.S. prior to 1994, implying a general safety recognition. It is a naturally occurring, biodegradable plant extract with no reported adverse interactions. Any ethanol used in its processing is fully evaporated, indicating negligible toxicity and environmental persistence.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Hydrolyzed Codonopsis Pilosula Root Extract is a valuable botanical offering comprehensive benefits for skin, including significant antioxidant, anti-inflammatory, and brightening effects, making it suitable for a wide range of skin concerns.
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