Science
Mechanism of Action
This ingredient delivers a rich profile of bioactive compounds, including flavonoids, carotenoids, saponins, and polysaccharides, in a readily absorbable form due to the hydrolysis process. It exerts its anti-inflammatory effects by inhibiting the production of nitric oxide (NO), a key pro-inflammatory radical. Furthermore, its flavonoid content provides significant antioxidant protection, shielding the skin from environmental stressors. The extract actively supports skin regeneration and wound healing by stimulating fibroblast adhesion, promoting cell proliferation, and encouraging new collagen development. These actions collectively lead to soothed, less irritated, and better hydrated skin.
Research
Clinical Evidence
High confidence7%
Key findings
- 01 Topical application demonstrated beneficial effects in promoting wound healing and providing significant soothing action.
- 02 Exhibited a dose-dependent inhibition of nitric oxide production by 50% without cytotoxicity, confirming its potent anti-inflammatory properties.
Transparency
Dusting Analysis
No data available in the provided research to suggest this ingredient is commonly 'dusted' or used below effective concentrations.
The Formula
Formulation
Stability
The hydrolysis process is specifically designed to enhance the bioavailability and overall efficacy of the extract. Studies have indicated high antioxidant activity when formulated in extract-loaded hydrogels at pH 5.5.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has concluded that various Calendula Officinalis extracts, including flower extract, are safe for use in cosmetic and personal care products. Acute toxicity studies indicate low overall toxicity, minimal skin irritation, no sensitization, and no phototoxicity. While generally safe, it may act as a mild ocular irritant. Allergic reactions are rare but remain a possibility for individuals with known sensitivities to plants in the Aster/Compositae family, such as ragweed or daisies.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Hydrolyzed Calendula Officinalis Flower Extract is a highly valuable ingredient, demonstrating potent anti-inflammatory, antioxidant, and wound-healing properties, making it exceptionally beneficial for sensitive and compromised skin.
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