Science
Mechanism of Action
This ingredient functions as a multifaceted skin conditioning agent, actively stimulating cellular regeneration and strengthening intercellular connections, thereby reducing transepidermal water loss (TEWL). Its bioactive composition, including peptides, amino acids, lactic acid, oligosaccharides, and enzymes, effectively soothes inflammation, minimizes redness, and modulates the skin's response to irritants. The filtrate enhances the skin's inherent self-defense against environmental aggressors like UV radiation, pollution, and thermal stress. It supports the repair of damaged cells and offers protection against UV-induced DNA damage, which consequently reduces signs of photoaging and promotes cellular recovery. Furthermore, it fosters a healthy skin microbiota, inhibiting pathogenic species while enabling beneficial microorganisms to flourish. The ingredient boosts the production of vital proteins and lipids within the skin barrier, augmenting its integrity and resilience. Possessing antioxidant properties, it neutralizes free radicals and mitigates oxidative damage. The fermentation process increases the bioavailability and efficacy of compounds by breaking down high-molecular weight structures into smaller, more absorbable components. Specifically, soy isoflavones, such as genistein and daidzein, within the fermented extract stimulate hyaluronic acid production, leading to improved skin hydration, viscoelasticity, and prevention of age-dependent hyaluronic acid depletion.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 In an essence, 1.0% Bifida Ferment Filtrate reduced facial skin TEWL by 20.62%, increased stratum corneum water content by 17.25%, and decreased skin erythema content by 21.01% after 28 consecutive days, demonstrating significant moisturizing, repairing, and soothing effects.
- 02 When used in a shampoo, a 1% concentration improved scalp itchiness and pain by 63.64% each, with an overall effectiveness rate of 78.79% after four consecutive weeks.
- 03 Bifidobacterium-fermented soymilk extract significantly enhanced hyaluronic acid production in human keratinocytes, human skin fibroblasts, and hairless mouse skin following two weeks of topical application. This effect is largely attributed to genistein, which helps prevent age-dependent loss of cutaneous hyaluronic acid.
- 04 Treatment with fermented soymilk (using L. paracasei MK1) resulted in a 164% increase in procollagen synthesis in human dermal fibroblasts and a 23% decrease in UV-induced pro-inflammatory cytokine TNF-α in human keratinocytes, demonstrating both anti-inflammatory and anti-aging effects.
- 05 Applying 10% bacterial extract (Bifida Ferment Lysate), a related ingredient, to sensitive, reactive skin improved barrier function and decreased skin sensitivity.
Transparency
Dusting Analysis
This ingredient is effective at concentrations ranging from 1% to 10% in clinical studies, well within the typical range for active compounds. The Cosmetic Ingredient Review (CIR) Expert Panel deemed related soy proteins safe up to 25%, indicating that it is utilized at meaningful, efficacious levels rather than for minimal label claims.
The Formula
Formulation
Stability
As a hydrolysate, this ingredient consists of compounds pre-broken down into smaller, more bioavailable components. The fermentation process further transforms high-molecular weight compounds into low-molecular weight ones, enhancing compatibility in various formulations. While optimal pH for the fermentation process has been noted (ranging from 3.42 to 6.82), specific optimal pH for the stability of the final cosmetic ingredient in formulation is not explicitly detailed.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel concluded that related soy proteins and peptides, including 'Hydrolyzed Soymilk Protein,' are safe in cosmetics at current use concentrations, with 'Hydrolyzed soy protein' showing no dermal irritation in human studies up to 25%. Lactobacillus ferment ingredients, including filtrates, have also been deemed safe by another CIR panel. While generally well-tolerated topically, rare instances of skin irritation or allergic reactions are possible. Due to a lack of specific topical usage data during pregnancy and breastfeeding, consultation with a healthcare professional is advised during these periods.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This multi-functional fermented ingredient offers significant, clinically supported benefits across skin hydration, barrier repair, anti-aging, and soothing, making it a valuable asset for diverse precision skincare formulations.
Related
Similar Ingredients
Finding similar ingredients…