Science
Mechanism of Action
This ingredient operates through several key mechanisms to fortify and rejuvenate the skin. It functions as a potent humectant, actively attracting and retaining moisture while stimulating aquaporin-3 synthesis to optimize water distribution within skin layers. Hydrolyzed Beta-Glucan significantly aids in skin barrier repair by promoting the synthesis of essential barrier components such as filaggrin (demonstrating a tenfold increase in synthesis in vitro/ex-vivo at 10 mg/ml) and ceramides, thereby effectively reducing transepidermal water loss. Its anti-inflammatory properties soothe irritated skin and mitigate redness, engaging with immune cells to bolster skin defense against environmental aggressors. Furthermore, it stimulates collagen production, which improves skin elasticity and firmness for visible anti-aging effects. As an antioxidant, it neutralizes free radicals and reactive oxygen species, protecting against oxidative damage, and it also promotes wound healing by stimulating fibroblast activity and tissue regeneration. The hydrolysis process reduces its molecular size, allowing for superior penetration, reaching into the dermis for comprehensive action.
Research
Clinical Evidence
High confidence1%
Key findings
- 01 Demonstrated a repair effect on the skin barrier within 48 hours, evidenced by reduced transepidermal water loss in a 19-participant volunteer study with damaged skin barriers.
- 02 Observed a tenfold increase in filaggrin synthesis in an in vitro study on human keratinocytes over five days, a result replicated in an ex-vivo study.
- 03 Beta-Glucan (with smaller fractions relevant to hydrolyzed forms) significantly reduced wrinkle depth and height, and improved skin roughness over 8 weeks.
- 04 Beta-Glucan formula applied twice daily for 6 weeks showed skin-improving effects in 13 participants with sensitive skin.
Transparency
Dusting Analysis
Clinical evidence supports efficacy for specific benefits at concentrations as low as 0.1% (anti-aging) and 1% (barrier repair). While broader skin improvements are noted up to 2%, effective results are seen at relatively low percentages, indicating that concentrations significantly below 0.1% may not provide notable benefits.
The Formula
Formulation
Stability
Hydrolyzed Beta-Glucan is water-soluble, with its hydrolyzed form specifically designed for enhanced solubility and bioavailability. It maintains stability across a broad pH range of 3.0 to 11.0, although precise pH control during its hydrolysis process (e.g., pH 4.5 for acid hydrolysis) is crucial for optimizing its characteristics and preventing degradation.
Safety
Safety Profile
While 'Hydrolyzed Beta-Glucan' itself has not been individually reviewed by the CIR and was excluded from a broader yeast-derived ingredient assessment due to its generic classification, Beta-Glucan as a category is widely regarded as a natural, safe, non-toxic, non-irritating, and non-sensitizing ingredient. The FDA considers *Saccharomyces cerevisiae*, a common source of beta-glucan, as Generally Recognized As Safe (GRAS) for specific food uses.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Hydrolyzed Beta-Glucan is a highly valuable, versatile ingredient, scientifically proven to enhance skin hydration, repair barrier function, soothe irritation, and visibly reduce signs of aging across all skin types.
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