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HYDROLYZED BEE LARVA EXTRACT.

Valuable / SKIN CONDITIONING - EMOLLIENT

Hydrolyzed Bee Larva Extract is a bio-active ingredient offering multifaceted benefits for skin health. It provides robust antioxidant protection, exhibits significant anti-aging properties by combating enzymatic degradation, and delivers anti-inflammatory support, making it a valuable skin conditioning agent across various skin types.

Summary

antioxidant anti-aging anti-inflammatory emollient skin conditioning

Science

Mechanism of Action

This extract functions by inhibiting key enzymes such as collagenase and hyaluronidase, which are responsible for the degradation of collagen and hyaluronic acid, thus preserving skin structure and hydration. It demonstrates potent antioxidant activity through nitric oxide inhibition and DPPH radical scavenging. Furthermore, it modulates inflammatory responses by decreasing the production of nitric oxide (NO) and interleukin-6 (IL-6) in stimulated macrophages. Specific peptides within the extract may also promote the synthesis of collagen and elastin, stimulate fibroblast proliferation, accelerate wound healing, and mimic growth factors, contributing to enhanced skin regeneration and appearance.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Apis mellifera larval hydrolysates demonstrated antioxidant properties with 43.8 ± 5.2% nitric oxide (NO•) inhibition.
  2. 02 Queen Bee Larvae (QBL) extract, at a concentration of 2.5 mg/mL, showed 88.66% DPPH radical scavenging, an activity level equivalent to 0.1 mg/mL of vitamin C.
  3. 03 QBL extract exhibited superior antioxidant potency with a half-maximal scavenging concentration (SC50) value of 0.84 mg/mL for DPPH scavenging.
  4. 04 The extract demonstrated anti-aging effects, including up to 78.1 ± 1.5% inhibition of hyaluronidase and inhibition of collagenase activity.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 4 – 4.5
0 7 14

Stability

Major Royal Jelly Proteins (MRJPs), key components of bee larval food, exhibit optimal stability at acidic pH values, specifically between pH 4.0 and 4.5. While protein solubility is pH-dependent, this range is noted for highest stability in formulated products.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Low

Direct regulatory status from CIR, SCCS, or FDA for 'HYDROLYZED BEE LARVA EXTRACT' is currently insufficient. However, related hydrolyzed honey proteins have been reviewed and deemed safe. Studies on Apis mellifera larval extracts show low irritation potential in HET-CAM tests, suggesting safety for topical application. Formulators should adhere to good manufacturing practices to monitor and limit potential impurities such as pesticides and endotoxins, a general consideration for all bee-derived ingredients.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Hydrolyzed Bee Larva Extract is a valuable, multi-functional ingredient demonstrating significant antioxidant, anti-aging, and anti-inflammatory benefits with low irritancy, making it suitable for a broad range of skin concerns despite pending direct regulatory assessment.

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