Science
Mechanism of Action
This ingredient operates by breaking down larger avocado proteins into smaller, more bioavailable peptides and amino acids via enzymatic hydrolysis, facilitating superior penetration into the epidermal layers. Its primary action involves stimulating the endogenous synthesis of critical hygroscopic molecules, notably Hyaluronic Acid, across both the epidermis and dermis, thereby significantly improving skin hydration. Furthermore, it boosts the production of Filaggrin and Transglutaminase, essential components that maintain the structural integrity and resistance of the stratum corneum, effectively reducing transepidermal water loss. Beyond hydration, it actively contributes to cellular repair and protection by upregulating Thioredoxin gene expression and Proteasome activity, which collectively reduce the accumulation of senescence-induced oxidized proteins.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 An emulsion containing Hydrolyzed Avocado Protein (as Effipulp®), when applied on skin explants every 24 hours for 72 hours, demonstrated stimulation of endogenous Hyaluronic Acid, Filaggrin, and Transglutaminase synthesis, crucial for preserving skin moisture.
- 02 Avocado peptides (a component of Effipulp®), in in-vitro tests on senescent fibroblasts over 72 hours, exhibited a +177% increase in Thioredoxin gene expression (a key repair system), a +43% increase in Proteasome activity (an elimination system), and a notable -44% reduction in oxidized proteins.
Transparency
Dusting Analysis
The Formula
Formulation
Conflicts
- Potential incompatibility with polysaccharides at neutral pH, which may lead to thermodynamic incompatibility and microphase separation.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has affirmed Hydrolyzed Avocado Protein as safe for use in cosmetics under current practices. It holds approval from both the European Union and the US FDA. While human studies indicated no sensitization, in vitro tests revealed potential eye irritation at higher concentrations (10% in BCOP and 20% in HET-CAM assays).
Your Skin
Skin Compatibility
Our Assessment
Verdict
Hydrolyzed Avocado Protein is a valuable ingredient, offering precise moisturizing, barrier-strengthening, and anti-aging benefits by stimulating key endogenous skin components and reducing oxidative stress.
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