Science
Mechanism of Action
This ingredient functions by reducing the expression of inflammatory cytokines such as IL-1, IL-4, IL-5, IL-6, IL-10, and IL-17, thereby calming skin irritation. It stimulates cell proliferation and tissue regeneration through mechanisms like promoting mitosis, stimulating dermal fibroblast growth, and encouraging the growth of cartilage and bone-forming cells. In wound healing, it accelerates closure, reduces scar formation by inhibiting the TGF-β signaling pathway, and enhances angiogenesis and collagen fiber distribution, partly due to the presence of Insulin-like Growth Factor-1 (IGF-1), which boosts cell growth, repair, and regeneration.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 A serum containing a related deer antler stem cell extract demonstrated a significant reduction in wrinkles by 48.09% to 60.31%, accelerated skin recovery time by 39.31% to 67.1%, and increased collagen density by 10.18% to 63.76% after two weeks of use. It also notably enhanced epidermal thickness by 106.1% to 121.7%. It is important to note these results were observed with a stem cell extract, not specifically Hydrolyzed Antler Velvet, and without a stated percentage concentration.
- 02 Enzymatically digested velvet antler peptides (EVAP) significantly accelerated the wound healing rate, reduced scar formation, promoted angiogenesis, increased the number of skin appendages (hair follicles and sebaceous glands), and improved the distribution pattern of collagen fibers in full-thickness skin wounds in rats.
- 03 Deer antler extract promoted hair follicle growth and, in human clinical trials, was found to promote hair growth without irritating the scalp.
Transparency
Dusting Analysis
Insufficient data available to determine if Hydrolyzed Antler Velvet is commonly used at sub-efficacious concentrations or to establish a dusting threshold.
The Formula
Formulation
Stability
Hydrolyzed Antler Velvet (as Velvet Antler Protamex Hydrolysate, VAPH) is optimally stored at pH 7.0. Deer Antler Peptides (DAPs) have shown good thermal and emulsion stability. For stability in oral products, citric acid and potassium sorbate have been used.
Safety
Safety Profile
This ingredient has not undergone specific review by the Cosmetic Ingredient Review (CIR) or the Scientific Committee on Consumer Safety (SCCS). While generally considered to have a low irritancy potential, raw deer velvet contains female sex hormones (estrone and estradiol) which may have estrogen-like activity. The potential hormonal effects of Hydrolyzed Antler Velvet in topical applications are not clearly defined in the provided data, but this hormonal content of the raw material is a consideration for individuals with hormone-sensitive conditions or those on hormonal medications.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Hydrolyzed Antler Velvet is a valuable multi-functional ingredient demonstrating significant potential in anti-aging, wound healing, and hair growth, though direct topical efficacy studies at specific concentrations for this exact form are limited and hormonal considerations warrant attention.
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