Science
Mechanism of Action
This hydrolyzed extract, rich in key bioactive compounds such as diarylheptanoids, flavonoids, tannins, and phenolic acids, exerts its benefits by modulating crucial cellular pathways. It effectively combats oxidative stress by upregulating endogenous antioxidant factors like Superoxide Dismutase (SOD), catalase, and Glutathione Peroxidase (Gpx). Its anti-inflammatory actions involve inhibiting the activation of the NLRP3 inflammasome and suppressing MAPKs/NF-kB signaling pathways, which subsequently reduces the production of inflammatory mediators such as nitric oxide (NO) and COX-2. Additionally, it can temper immune responses by decreasing blood eosinophils, serum IgE, and Th2-related cytokines (e.g., IL-4, IL-5, IL-13), contributing to an overall calming effect on the skin. The hydrolysis process is believed to enhance the bioavailability and biological potency of its active constituents.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Alnus Japonica hot water extract (AJHW) significantly enhanced cell viability in C2C12 myoblasts exposed to H2O2-induced oxidative stress, demonstrating a dose-dependent increase, reaching 14.5% at 20 μg/mL.
- 02 AJHW increased cell viability in C2C12 murine skeletal muscle cells treated with dexamethasone, suggesting a protective role against cellular damage.
- 03 Topical application of Alnus japonica leaf and bark extract effectively suppressed the development of atopic dermatitis-like skin lesions in NC/Nga mice, concurrently decreasing blood eosinophils, serum IgE, and Th2-related cytokine levels (IL-4, IL-5, IL-13).
- 04 Enzymatic hydrolysis of an extract from a related species, Alnus sibirica, exhibited more potent antioxidant and anti-inflammatory activity than its non-hydrolyzed counterpart. Isolated compounds inhibited NO production (IC50 16.7-27.2 μg/mL) and reduced COX-2 levels (IC50 20.7-27.3 μg/mL).
Transparency
Dusting Analysis
The Formula
Formulation
Stability
While a specific optimal pH range for HYDROLYZED ALNUS JAPONICA STEM EXTRACT in cosmetic formulations is currently unavailable, certain Alnus japonica components like oregonin and hirsutanone have shown stability at highly acidic pH 1.2. As a botanical extract rich in phenolic compounds, it may be susceptible to oxidative degradation over time, which could potentially lead to slight acidification of formulations. Hot water extraction methods are generally favored over ethanol due to concerns regarding human safety and the stability of active compounds.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has not yet conducted a specific review of HYDROLYZED ALNUS JAPONICA STEM EXTRACT. Therefore, its comprehensive safety profile, including potential irritancy or sensitization, is currently unknown and subject to ongoing evaluation, as indicated by sources like Paula's Choice and INCIDecoder.
Your Skin
Skin Compatibility
Our Assessment
Verdict
HYDROLYZED ALNUS JAPONICA STEM EXTRACT is a valuable ingredient with significant potential for precision skincare, based on preclinical evidence of its potent antioxidant and anti-inflammatory effects, pending further human clinical trials and full safety assessment.
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References
Sources