Science
Mechanism of Action
This extract operates by activating Transient receptor potential vanilloid 3 (TRPV3), a key pathway for rapid skin barrier repair. Its inherent antioxidant capabilities neutralize damaging free radicals, and its anti-inflammatory properties calm irritation. It contributes to a more uniform complexion by inhibiting tyrosinase activity and melanin synthesis, while also supporting cellular longevity and dermal integrity through upregulation of telomerase activity and crucial barrier proteins like filaggrin. Additionally, it functions as a humectant, promoting skin hydration.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Accelerates skin barrier restoration by activating Transient receptor potential vanilloid 3 (TRPV3).
- 02 Exhibits significant antioxidant and anti-inflammatory effects.
- 03 Effectively inhibits free radical generation and suppresses tyrosinase activity, suggesting skin whitening/brightening.
- 04 Shows anti-acne effects against Propionibacterium acnes (observed with Agrimonia pilosa Ledeb. extract at 0.05 mg/mL MIC).
- 05 Demonstrates anti-aging effects, including upregulation of telomerase activity and altered expression of skin-significant genes like filaggrin.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
While the water extract demonstrates notable stability across a wide range of temperatures and pH, long-term stability of flavonoid glucuronides within topical formulations can be compromised, particularly under accelerated testing conditions.
Safety
Safety Profile
Specific safety assessments by regulatory bodies such as CIR, SCCS, or FDA for Hydrolyzed Agrimonia Pilosa Leaf Extract are currently unavailable. General toxicity data for non-hydrolyzed Agrimonia pilosa extract concerning oral, dermal, or inhalation routes remain undetermined.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This multifaceted botanical extract offers significant benefits for skin health, notably enhancing barrier function, combating oxidative stress and inflammation, and supporting an even, youthful complexion.
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References
Sources