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HYDROLYZED ACTINIDIA ARGUTA LEAF EXTRACT.

Valuable / SKIN CONDITIONING

Derived from the hardy kiwi plant, Hydrolyzed Actinidia Arguta Leaf Extract is a multi-functional ingredient prized for its potent anti-inflammatory, antioxidant, and anti-aging properties. It actively contributes to improving skin barrier function, enhancing hydration, and promoting overall skin health and appearance, making it suitable for a wide range of precision skincare applications.

Summary

Anti-inflammatory Antioxidant Anti-aging Skin-conditioning Barrier support Photoprotective Anti-acne Depigmenting Emollient Wound healing Hydration enhancer Elasticity booster

Science

Mechanism of Action

This advanced extract exerts its benefits through several interconnected pathways. It functions as a robust anti-inflammatory agent by inhibiting enzymes like elastase and hyaluronidase, modulating T-helper cytokine responses (Th1/Th2), and suppressing the overproduction of IgE. It also targets key inflammatory cytokines, including TNF-α, IL-4, IL-5, IL-13, and IFN-γ, while downregulating chemokines and antimicrobial peptides via NF-κB and STAT signaling inhibition. Rich in phytochemicals like polyphenols and Vitamin C, it provides significant antioxidant protection by scavenging free radicals and inhibiting erythrocyte hemolysis. Its anti-aging efficacy stems from elastase and hyaluronidase inhibition, supporting collagen synthesis, enhancing skin density, hydration, and elasticity, and offering photoprotection. Furthermore, it aids in skin conditioning, can contribute to anti-acne effects, depigmentation, and wound healing, and promotes filaggrin expression, a crucial protein for a healthy skin barrier.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Methanol extract of A. arguta leaves inhibited NLRP3 ubiquitination and suppressed the secretion of caspase-1 and IL-1β in vitro, with confirmed effects in a mouse model of peritonitis.
  2. 02 Topical application of a water-soluble Actinidia arguta extract (PG102) ameliorated imiquimod-induced psoriasis-like skin inflammation in mice, reducing skin thickness and IL-17A levels.
  3. 03 A hydroalcoholic leaves extract of Actinidia arguta demonstrated in-vitro and ex-vivo anti-aging effects by inhibiting elastase and hyaluronidase enzymes, and was found to be non-irritant to skin.
  4. 04 An extract containing Actinidia arguta (ACTPER) ameliorated dry skin-induced itch in a mice model and promoted filaggrin expression in HaCaT cells.

Transparency

Dusting Analysis

Not commonly dusted

Insufficient data available to perform a dusting analysis for this ingredient.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The antioxidant compounds within Actinidia arguta extracts are known for their chemical instability, suggesting the potential need for suitable delivery systems, such as microparticles, to ensure protection and controlled release in formulations.

Synergies

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Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While the Cosmetic Ingredient Review (CIR) and Scientific Committee on Consumer Safety (SCCS) have not specifically reviewed Hydrolyzed Actinidia Arguta Leaf Extract, general studies indicate that Actinidia arguta leaf extract is 'not irritant to skin application'. An unhydrolyzed Actinidia arguta extract has received a 'Generally Recognized As Safe' (GRAS) notice from the FDA for food use, though this doesn't directly extend to topical cosmetic applications. Cell viability assays have shown no adverse effects on HT29-MTX cells up to 1000 µg/mL.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Hydrolyzed Actinidia Arguta Leaf Extract is a valuable ingredient, offering broad-spectrum benefits from anti-inflammatory and antioxidant protection to anti-aging and skin barrier support, with low irritancy potential.

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