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Moumoujus

HYDRANGENOL.

Valuable CAS 480-47-7 / HAIR CONDITIONING, SKIN CONDITIONING

Hydrangenol is a potent polyphenol identified as a primary active component within Hydrangea serrata extract. It offers comprehensive benefits for skin health, specifically targeting anti-aging, hydration, and barrier enhancement through multiple biochemical pathways.

Summary

Anti-aging Moisturizing Hydrating Wrinkle reduction Skin barrier support Collagen boosting Antioxidant Anti-inflammatory Keratinocyte proliferation

Science

Mechanism of Action

Hydrangenol delivers antiphotoaging effects by reducing key matrix metalloproteinases (MMP-1, MMP-3) and inflammatory mediators (COX-2, IL-6). It significantly boosts skin moisturization by increasing expression of essential barrier components like involucrin, filaggrin, and aquaporin-3 (AQP3), while promoting hyaluronic acid (HA) production through the downregulation of hyaluronidase (HYAL)-1 and -2. This compound also stimulates Pro-collagen type 1 (COL1A1) expression, mitigates phosphorylation of MAPKs (ERK, p38), AP-1 subunits (c-Fos, c-Jun), and STAT1, further supporting anti-aging. Additionally, Hydrangenol enhances the skin's antioxidant defense by upregulating Nrf2, HO-1, NQO-1, GCLM, and GCLC, and promotes keratinocyte proliferation for improved skin regeneration.

Research

Clinical Evidence

High confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH 4 – 7
0 7 14

Stability

Hydrangenol exhibits improved stability and content in extracts as pH decreases within the 4.0-7.0 range, favoring weakly acidic conditions. Precipitation or phase separation during preparation may be resolved with heat or sonication. Solutions prepared for in vivo applications are recommended for fresh preparation and immediate use, suggesting potential degradation over time in solution.

Conflicts

  • Known as a strong contact sensitizer, careful formulation is essential to mitigate potential skin irritation or allergic reactions, particularly for sensitive individuals.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

Hydrangenol is identified as a strong contact sensitizer and has induced allergic contact dermatitis in patch tests. However, a clinical study utilizing 0.5% Hydrangea serrata hot water extract (where Hydrangenol is the primary active) reported no adverse reactions and was deemed safe for topical application, suggesting that appropriate formulation can mitigate inherent risks. The ingredient's safety has not been reviewed by CIR.

Your Skin

Skin Compatibility

No Normal
Yes Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Hydrangenol is a valuable active for advanced anti-aging and hydration formulations, offering significant benefits across multiple skin pathways; however, its classification as a strong contact sensitizer necessitates meticulous formulation to ensure consumer safety and mitigate high irritancy potential.

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