Science
Mechanism of Action
Hydrangea Serrata Leaf Extract (HSLE) primarily functions through its active compound, hydrangenol, which exhibits significant antioxidant activity. It targets key pathways to combat skin aging, specifically by downregulating matrix metalloproteinases (MMPs) like MMP-1 and MMP-3, enzymes responsible for collagen degradation, thus supporting increased collagen content. HSLE also mitigates UVB-induced damage by inhibiting collagen breakdown and MMP activation via the MAPK/AP-1 signaling pathway. For hydration, it upregulates natural moisturizing factors such as hyaluronic acid and suppresses hyaluronidase activity at the mRNA level. Furthermore, it stimulates COL1A1 expression and keratinocyte proliferation, aiding in cellular regeneration and strengthening the skin barrier. It also possesses inherent anti-inflammatory properties.
Research
Clinical Evidence
Medium confidence0.5%
Key findings
- 01 A clinical study demonstrated significant improvements in skin wrinkle depth and moisturizing levels in subjects utilizing a 0.5% concentration of Hydrangea Serrata Leaf Extract compared to a placebo group.
Transparency
Dusting Analysis
No data suggests common dusting or indicates a concentration at which it becomes a concern for topical formulations.
The Formula
Formulation
Stability
The primary active constituent, hydrangenol, exhibits enhanced stability and higher content within an acidic pH range, specifically optimal at pH 4.0, with stability progressively decreasing as pH approaches neutrality.
Safety
Safety Profile
While the Cosmetic Ingredient Review (CIR) has not specifically evaluated topical use, Hydrangea serrata extract is generally considered safe. This is supported by its inclusion on the US GRAS list and approval by the EU Cosmetics Directive and Korean MFDS. Oral studies in humans and rats showed no significant toxicity. Rare individual cases of skin irritation or itching may occur, suggesting a low potential for sensitization.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Hydrangea Serrata Leaf Extract is a valuable ingredient for anti-aging and skin hydration due to its proven ability to improve wrinkles, boost moisture, and support collagen health while demonstrating a favorable safety profile.
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