Science
Mechanism of Action
The efficacy of Hydnocarpus anthelminticus seed extract is attributed to its complex composition, including cyclopentenyl fatty acids, triglycerides, sterols, and flavonolignans such as hydnocarpin. These compounds collectively contribute to its reported antibacterial, anti-inflammatory, and antioxidant properties. Its wound healing potential is mediated by activating macrophages, which subsequently increase the production of TNF-α and nitric oxide (NO), and stimulate the secretion of VEGF, TGF-β, and MMP-9, thereby promoting angiogenesis and fibroblast proliferation.
Research
Clinical Evidence
Medium confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The extract contains components with solubility in both polar (e.g., ethanol, water) and non-polar (oil) solvents, though its primary solubility is noted in alcohol/oil due to its oil-yielding seeds.
Safety
Safety Profile
No specific CIR, SCCS, or FDA safety status has been established for Hydnocarpus anthelminticus seed extract. However, an ethyl acetate extract of Hydnocarpus laurifolia (a related species) was deemed 'toxicologically safe' with an IC50 of 482.54 μg/ml on normal PBMCs, suggesting low cytotoxicity to normal cells. Cosmetic manufacturers are mandated to conduct comprehensive product safety assessments.
Your Skin
Skin Compatibility
Our Assessment
Verdict
With its rich composition of bioactive compounds and extensive traditional use for various skin concerns, Hydnocarpus anthelminticus seed extract offers valuable multi-functional potential for targeted skin repair, protection, and conditioning within precision skincare formulations.
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References
Sources