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HYALURONIC ACID/POLYGLUTAMIC ACID CROSSPOLYMER.

Valuable / ANTI-SEBUM, ANTIOXIDANT, HUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

This advanced hybrid ingredient synergistically combines hyaluronic acid (HA) with polyglutamic acid (PGA) through a crosslinking process. It forms an optimized network structure on the skin, delivering superior, prolonged hydration and reinforcing the skin's protective barrier more effectively than either component alone.

Summary

humectant moisturizer skin conditioning skin protecting antioxidant anti-sebum barrier repair improves elasticity promotes cell growth and regeneration

Science

Mechanism of Action

The Hyaluronic Acid/Polyglutamic Acid Crosspolymer functions as a potent humectant, significantly drawing and retaining water within the skin. Hyaluronic Acid (HA) typically binds up to 1,000 times its weight in water, helping to visibly plump the skin and reduce the appearance of fine lines. Polyglutamic Acid (PGA) surpasses this, capable of holding up to 5,000 times its weight in water. The crosslinked structure enhances the stability and performance of both polymers, forming a resilient, lightweight film on the skin's surface. This film effectively minimizes transepidermal water loss (TEWL) and bolsters the skin barrier. Additionally, PGA actively stimulates the skin's natural production of Natural Moisturizing Factors (NMFs), contributing to improved elasticity, texture, and supporting cellular regeneration, alongside possessing antioxidant properties.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 5.5 – 7.5
0 7 14

Stability

Crosslinking hyaluronic acid and polyglutamic acid significantly enhances their inherent stability and extends degradation time. Hyaluronic acid is known to be less stable in low pH formulations. For optimal stability in solution, particularly for components like Sodium Hyaluronate, a pH range of 5.5 to 7.5 is recommended. Formulations such as creams, with their higher water content, tend to offer greater stability compared to ointments.

Synergies

  • Hyaluronic Acid (HA)
  • Polyglutamic Acid (PGA)
  • Natural Moisturizing Factors (NMFs)

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Low

Both Hyaluronic Acid and its salts, along with Polyglutamic Acid, have demonstrated excellent safety profiles. The Cosmetic Ingredient Review (CIR) Expert Panel has deemed HA and its derivatives safe for use in cosmetics. PGA exhibits a low risk of irritation and is well-tolerated, with reports indicating no irritation or rashes. The combined crosspolymer is considered safe for twice-daily application with no known compatibility issues. It's important to note that while FDA-approved cross-linked HA is utilized in injectable dermal fillers, a specific FDA status for the topical 'HYALURONIC ACID/POLYGLUTAMIC ACID CROSSPOLYMER' was not found in the research data.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

This crosspolymer is a valuable ingredient, expertly fusing two powerful humectants to provide enhanced, stable hydration, robust barrier support, and a comprehensive range of skin benefits across all skin types.

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