Science
Mechanism of Action
HYALURONATE RH-OLIGOPEPTIDE-1 functions through a dual mechanism. Rh-Oligopeptide-1, recognized as Epidermal Growth Factor (EGF), acts as a cell-communicating ingredient. It stimulates the growth, proliferation, and differentiation of epidermal cells, thereby promoting skin regeneration, aiding wound healing, and encouraging collagen synthesis. It also boosts the skin's natural hyaluronic acid production and can mitigate inflammation. The Hyaluronate component, a powerful humectant, attracts and retains water in the skin, critically maintaining skin elasticity, supporting the regeneration of a damaged skin barrier, and visibly plumping wrinkles associated with water loss.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Studies involving a serum containing barley bioengineered epidermal growth factor (Oligopeptide-1/EGF) have reported statistically significant improvements in the appearance of fine lines, rhytids, skin texture, pore size, and various dyschromatic conditions within the first month of use. These findings also indicate a role in accelerating wound healing, enhancing skin hydration, stimulating collagen production, and diminishing dark spots.
- 02 A clinical trial evaluating a combination of hyaluronic acid serum and antioxidant cream showed positive outcomes for aging neck skin, including reductions in wrinkles, laxity, pigmentation, erythema, dryness, and improved texture, with high patient satisfaction.
Transparency
Dusting Analysis
While rh-Oligopeptide-1 demonstrates promising biological activities, specific effective cosmetic concentrations for this combined ingredient are not definitively established in the provided research. The efficacy reported in studies, primarily on rh-Oligopeptide-1, is inherently concentration-dependent. Furthermore, scientific reviews have raised concerns about the lack of proven preclinical bioactivity for sh-oligopeptide-1 in cosmetics and the classification of active EGF as a potent, unauthorized drug in medical treatments, implying a need for careful formulation to ensure active levels are present and efficacious.
The Formula
Formulation
Stability
Both Hyaluronic Acid and Oligopeptide-1 are sensitive to pH; their ideal activity is maintained within a pH range of 5.0 to 8.0. For Hyaluronic Acid, temperatures above 25°C can lead to denaturation, with optimal storage between 2°C and 8°C. Oligopeptide-1 is highly susceptible to microbial contamination, where enzymatic decomposition by microorganisms can significantly reduce its activity.
Synergies
- The combination of hyaluronate and rh-Oligopeptide-1 inherently creates a synergy, where hyaluronate's hydrating and barrier-repairing benefits can support and enhance the regenerative and reparative actions of the epidermal growth factor.
Safety
Safety Profile
The CIR Expert Panel has concluded that Hyaluronic Acid and its salts (including Sodium Hyaluronate) are safe for cosmetic use at concentrations up to 2%. For Oligopeptide-1 (EGF), while generally considered well-tolerated, some scientific reviews express concerns regarding the lack of proven preclinical bioactivity for sh-oligopeptide-1 and note that active EGF is classified as a potent, unauthorized drug for medical treatments, not a cosmetic. There is no specific SCCS assessment for the combined HYALURONATE RH-OLIGOPEPTIDE-1, and direct FDA cosmetic approval for this specific combination is not available, though Hyaluronic Acid has approved medical uses.
Your Skin
Skin Compatibility
Our Assessment
Verdict
HYALURONATE RH-OLIGOPEPTIDE-1 offers promising benefits for skin regeneration, hydration, and anti-aging due to its dual components, yet significant scientific and regulatory concerns surrounding the preclinical bioactivity and classification of its EGF component necessitate careful consideration in cosmetic formulations.
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