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Moumoujus

HUMULUS LUPULUS OIL.

Valuable CAS 8007-04-3 / 8060-28-4 / FRAGRANCE

Humulus Lupulus Oil, extracted from hops, is a potent botanical ingredient recognized for its multifaceted benefits. It offers robust antioxidant and anti-inflammatory properties, actively combating photoaging and oxidative stress, while also supporting skin barrier function and regulating sebum production.

Summary

Anti-aging Antioxidant Anti-inflammatory Barrier strengthening Oil regulation Masking

Science

Mechanism of Action

This oil functions through its rich composition of flavonoids and antioxidants, which neutralize free radicals and mitigate oxidative stress, thereby reducing the appearance of fine lines, wrinkles, and age spots. Hop bitter acids contribute by scavenging radicals and inhibiting lipid peroxidation, exhibiting antibiotic effects against Gram-positive bacteria. Crucially, its myrcene content actively protects dermal fibroblasts from photoaging by decreasing reactive oxygen species (ROS), matrix metalloproteinases (MMP-1, MMP-3), and interleukin (IL)-6, while concurrently boosting transforming growth factor (TGF)-β and Type I procollagen synthesis. Furthermore, it aids in regulating skin's oil balance and reinforcing its natural protective barrier.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

0.2%

Transparency

Dusting Analysis

Commonly dusted
Min. effective
0.2%
Red flag below
>0.2%

Humulus Lupulus Oil has a strict maximum concentration limit of 0.2% set by the International Fragrance Association (IFRA) due to potential sensitizing constituents. Exceeding this threshold, or improper formulation, significantly elevates the risk of dermal irritation, sensitization, or other adverse effects from components like 8-prenylnaringenin, β-myrcene, and sesquiterpene lactones.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Optimal stability is achieved with anaerobic and cold storage, as the oil's content can degrade significantly under aerobic conditions and at room temperature.

Conflicts

  • High concentrations of 8-prenylnaringenin (potential estrogenic effects)
  • High concentrations of β-myrcene (potential dermal irritation)
  • High concentrations of quercetin (potential genotoxicity)
  • Sesquiterpene lactones (potential dermal sensitization)

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
0.2%
Sensitization risk Moderate

The Cosmetic Ingredient Review (CIR) Expert Panel deems Humulus Lupulus Oil safe when formulated to be non-sensitizing and within restricted concentrations. Specific constituents such as 8-prenylnaringenin, β-myrcene, and quercetin warrant careful control due to potential estrogenic effects, dermal irritation, and genotoxicity at elevated levels. The presence of sesquiterpene lactones also contributes to a moderate risk of dermal sensitization, necessitating adherence to the 0.2% maximum concentration established by IFRA.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Humulus Lupulus Oil is a valuable ingredient, providing significant antioxidant, anti-aging, and skin-balancing benefits, provided it is precisely formulated at or below its strict 0.2% concentration limit to mitigate potential irritation and sensitization risks.

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