Science
Mechanism of Action
This extract operates on multiple fronts to enhance skin vitality. It effectively reduces reactive oxygen species (ROS) by both scavenging existing free radicals and inhibiting their generation, a key function attributed to its flavonoid content, including luteolin and quercetin. Its anti-inflammatory properties are demonstrated by the suppression of NF-κB p65-dependent inflammatory responses, thereby mitigating skin irritation. Additionally, the extract exhibits anti-aging potential by modulating the AMPK-SIRT1 pathway.
Research
Clinical Evidence
Medium confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
To maintain the stability and efficacy of its active humulose flavonoids, the extract should be stored in a cool, dry environment, protected from light and elevated temperatures.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has not specifically evaluated Humulus Japonicus Extract. While Humulus Lupulus (Hops) Extract, a different species, has been deemed safe in cosmetics when non-sensitizing, this assessment does not directly apply to Humulus Japonicus. Data regarding oral, parenteral, dermal, and inhalation toxicity for Humulus Japonicus Extract are currently 'Not determined'. It is noteworthy that direct physical contact with the raw Humulus japonicus plant's stems and leaves can cause abrasive irritation due to its rough texture, though this concerns the plant itself, not necessarily purified extracts.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This multi-functional botanical extract is a valuable asset in precision skincare, offering robust antioxidant defense, significant anti-inflammatory benefits, and promising anti-aging properties suitable for all skin types, pending further comprehensive safety assessments.
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References
Sources