Science
Mechanism of Action
Humulus japonicus extract (HJE) exerts its effects through several biological pathways. It effectively neutralizes reactive oxygen species (ROS) and boosts the skin's inherent antioxidant defenses by upregulating enzymes such as glutathione and catalase. Furthermore, HJE modulates the AMPK-SIRT1 pathway, which contributes to anti-aging by enhancing sirtuin 1 and AMP-activated protein kinase activity. Its anti-inflammatory action primarily involves suppressing NF-κB p65-dependent responses and inhibiting the release of pro-inflammatory mediators like IL-1β and TNF-α.
Research
Clinical Evidence
Medium confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Studies frequently report the use of ethanolic extracts, suggesting good stability in alcohol-based formulations.
Safety
Safety Profile
Specific safety assessments for Humulus japonicus extract in cosmetic applications by agencies like CIR, SCCS, or FDA are not currently available. While topical application has been shown to ameliorate irritant contact dermatitis, indicating low direct irritancy, it is important to note that Humulus japonicus pollen is a documented allergen for weed pollinosis, a factor to consider for highly sensitive individuals.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Humulus japonicus extract is a valuable multi-functional ingredient offering significant antioxidant, anti-inflammatory, and anti-aging benefits, making it highly suitable for formulations aimed at protecting, soothing, and revitalizing sensitive and aging skin.
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References
Sources