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Moumoujus

HUMAN TOOTH PULP STEM CELL CONDITIONED MEDIA.

Insufficient Data / SKIN CONDITIONING

Human Tooth Pulp Stem Cell Conditioned Media (HTPSC-CM) is a cell-free solution containing a rich array of bioactive molecules secreted by human dental pulp stem cells. This advanced ingredient is designed to leverage the natural regenerative capacity of stem cells to promote tissue repair, enhance cell vitality, and mitigate inflammatory responses within the skin.

Summary

Skin regeneration Anti-inflammatory Cell proliferation Tissue repair Anti-aging

Science

Mechanism of Action

HTPSC-CM operates via paracrine effects, delivering a 'secretome' of growth factors, cytokines, and proteins directly to skin cells. These signaling molecules stimulate various cellular processes, including proliferation, survival, migration, and differentiation, crucial for tissue remodeling. On the skin, HTPSC-CM supports wound healing, offers protection against apoptosis, reduces inflammation, and facilitates general tissue repair and regeneration.

Research

Clinical Evidence

Medium confidence
Effective range 50–100%
Optimal

100%

Key findings

  1. 01 A 50% concentration significantly increased osteoblast proliferation, maturation, and mineralization in vitro, suggesting regenerative potential.
  2. 02 Both 50% and 100% Stem Cells from Human Exfoliated Deciduous Teeth Conditioned Media (SHED CM) improved cell viability, with 100% CM being more efficient. Specifically, 100% CM boosted cell viability by 28.09 ± 4.64%, while 50% CM increased it by 4.78 ± 4.64% compared to a serum-free control. Furthermore, 100% SHED CM reduced H2O2-mediated apoptosis, leading to a 55.68 ± 4.8% increase in cell viability at 48 hours.
  3. 03 A concentrated conditioned medium demonstrated beneficial effects on dentin-pulp complex regeneration in rats, improving hard tissue organization and reducing inflammatory signs.
  4. 04 Intravenous administration of SHED-CM in mice effectively inhibited radiation-induced skin ulcer formation, dermal thickness, and epithelial hyperplasia.

Transparency

Dusting Analysis

Not commonly dusted

Insufficient data is available to assess if this ingredient is commonly 'dusted' or used at concentrations below a perceived efficacy threshold in cosmetic formulations.

The Formula

Formulation

Solubility
Water
Optimal pH 7.2 – 7.8
0 7 14

Stability

This ingredient is not suitable for long-term storage at room temperature. Optimal stability requires storage at 2-8°C for up to 6 months with light protection, or at -80°C for extended periods. Fluctuations in the concentration of specific bioactive components within the conditioned medium may impact the consistency of regenerative outcomes.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

As a cell-free therapy, HTPSC-CM inherently minimizes the risk of inflammation and other complications associated with live cell therapies. Additionally, dental pulp stem cells exhibit low immunogenicity, which contributes to a favorable safety profile for regenerative applications. Specific regulatory status (CIR, SCCS, FDA) for topical cosmetic use is currently not established.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Human Tooth Pulp Stem Cell Conditioned Media demonstrates significant preclinical potential in promoting regeneration, enhancing cell viability, and exerting anti-inflammatory effects; however, further human topical research is essential to definitively establish its precise efficacy and optimal application in skincare formulations.

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