Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

HUMAN EMBRYONIC INDUCED SKIN PLURIPOTENT CELL CONDITIONED MEDIA.

Insufficient Data / ANTIOXIDANT, HAIR CONDITIONING, HUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

Human Embryonic Induced Skin Pluripotent Cell Conditioned Media (hEISC-CM) is a cell-free supernatant derived from cultured human embryonic induced skin pluripotent cells. It contains a complex blend of bioactive molecules such as growth factors, cytokines, and exosomes, engineered to enhance skin's regenerative processes and bolster overall skin resilience.

Summary

Antioxidant Hair Conditioning Humectant Skin Conditioning Skin Protecting

Science

Mechanism of Action

This conditioned media delivers a diverse array of soluble signaling molecules, including potent growth factors, cytokines, and exosomes, directly to skin cells. These bioactive components stimulate crucial cellular functions like proliferation, differentiation, and natural healing, modulating inflammatory responses and accelerating cellular turnover. This action aims to refine skin texture, promote a more even tone, boost radiance, strengthen the skin barrier, enhance hydration, and encourage the production of vital extracellular matrix proteins such as collagen and elastin, thereby improving skin structure and elasticity.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 One study indicated that a 5% concentration of Human Adipose Stem Cell-Conditioned Medium (hASC-CM) improved various photoaged skin parameters, including pores, wrinkles, spot polarization, UV spots, and skin tone, over 8 weeks with twice-daily application. However, this study specifically utilized hASC-CM, not Human Embryonic Induced Skin Pluripotent Cell Conditioned Media, limiting direct extrapolation of its findings.

Transparency

Dusting Analysis

Not commonly dusted

As a complex biological medium rather than a single synthetic active, this ingredient is not typically associated with 'dusting' concerns, which generally apply to specific actives used at minimal concentrations for label claims.

The Formula

Formulation

Solubility
Water
Optimal pH 7.1 – 7.4
0 7 14

Stability

The active protein and growth factor components within the conditioned media are water-soluble. Optimal stability for these bioactive factors is observed within a physiological pH range, specifically between 7.1 and 7.4. Due to its biological nature, it is sensitive to degradation and typically requires storage at low temperatures (e.g., 2-8°C), with a limited shelf life (e.g., approximately two weeks once thawed for cell culture applications).

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

This ingredient has not undergone direct review by prominent cosmetic safety bodies such as CIR or SCCS. Its regulatory status varies significantly by region: it is generally considered illegal for cosmetic use within the EU, while human-derived growth factors (key components of conditioned media) are often permitted in US cosmetics. The Korean Ministry of Food and Drug Safety maintains specific regulations for human-derived cell and tissue culture materials in cosmetic raw materials. While concerns about teratoma formation exist for undifferentiated induced pluripotent stem cells (iPSCs) in therapeutic contexts, conditioned media is cell-free, significantly mitigating these specific risks for cosmetic applications.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While Human Embryonic Induced Skin Pluripotent Cell Conditioned Media holds theoretical promise for skin rejuvenation, the current lack of direct clinical efficacy data and comprehensive safety assessments from major regulatory bodies warrants a cautious approach.

Related

Similar Ingredients

Finding similar ingredients…