Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

HUMAN BONE MARROW STEM CELL CONDITIONED MEDIA EXTRACT.

Valuable / BLEACHING, HUMECTANT, ORAL CARE, SKIN CONDITIONING, SKIN PROTECTING, SOLVENT

Derived from human bone marrow stem cells, this extract is a powerhouse of bioactive molecules crucial for skin regeneration and rejuvenation. It works by delivering essential growth factors, cytokines, and peptides that promote cellular vitality and enhance the skin's natural repair processes. The ingredient aims to improve overall skin health, addressing concerns from hydration to elasticity and inflammatory responses.

Summary

Skin-Conditioning Humectant Skin Protecting

Science

Mechanism of Action

This extract operates by supplying a rich cocktail of growth factors (such as VEGF, EGF, FGF, TGF-β, PDGF, HGF, IGF-1, KGF), cytokines (including IL-6, IL-10), and peptides to the skin. These molecules stimulate the proliferation and migration of dermal fibroblasts and keratinocytes, which are vital for producing extracellular matrix components like collagen and elastin. This intricate cellular communication leads to visible improvements in skin elasticity, reduction of wrinkles, and enhanced hydration. Furthermore, it exhibits antioxidant properties to combat oxidative stress and immunomodulatory effects that reduce inflammation, supporting the skin's natural healing capabilities.

Research

Clinical Evidence

Medium confidence
Effective range 1–5%
Optimal

5%

Key findings

  1. 01 A study evaluating conditioned media (specifically Adipose-Derived Stem Cell Conditioned Media, ADSC-CM) demonstrated a notable increase in skin moisture, a significant reduction in transepidermal water loss (TEWL), and visible improvements in skin tone (whitening) and wrinkle depth. These benefits were particularly pronounced when the media was delivered via polymersomes, suggesting enhanced absorption.
  2. 02 Topical application was observed to activate cellular membrane receptors, contributing to promoted healing and reduced inflammation within the skin.

Transparency

Dusting Analysis

Not commonly dusted

Data on common dusting practices or thresholds for this specific ingredient is not available within the provided research. Given its complex biological nature and potential high cost, it is less likely to be 'dusted' in formulations where efficacy at meaningful concentrations is paramount.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Aqueous cosmetic compositions containing stem cell conditioned medium can maintain stability for up to 3 years. For cryo-dehydrated forms, when reconstituted into a cosmetic base, stability is noted for approximately one week under refrigerated conditions.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Formal safety assessments by CIR, SCCS, or FDA are not yet available for Human Bone Marrow Stem Cell Conditioned Media Extract. However, existing studies indicate it is safely obtained and well-tolerated when applied topically, showing low cytotoxicity. It is acellular, containing no human DNA, and has not elicited adverse immune reactions in various studies, suggesting a low risk of sensitization. No serious adverse events have been reported in clinical applications of similar mesenchymal stem cell conditioned media.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

This advanced ingredient offers significant regenerative and anti-inflammatory benefits, making it a valuable addition for comprehensive skin rejuvenation and repair, suitable for all skin types due to its low irritancy potential.

Related

Similar Ingredients

Finding similar ingredients…