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HOVENIA DULCIS FRUIT EXTRACT.

Valuable / SKIN CONDITIONING

Hovenia Dulcis Fruit Extract, derived from the Japanese Raisin Tree, is a botanical powerhouse rich in flavonoids and phenolic acids. It is recognized for its potent antioxidant and anti-inflammatory properties, effectively soothing skin and reducing oxidative stress. Clinical research indicates its ability to modulate key inflammatory pathways, offering significant benefits for irritated skin conditions.

Summary

Antioxidant Anti-inflammatory Soothing Reduces oxidative stress

Science

Mechanism of Action

Hovenia Dulcis Fruit Extract operates through a dual mechanism of action, leveraging its high content of flavonoids and phenolic acids for both antioxidant and anti-inflammatory benefits. It actively mitigates oxidative stress and suppresses the release of pro-inflammatory cytokines such as IL-1α and IL-1β, alongside chemokines like CCL-20 and CXCL-8. Furthermore, it modulates critical cellular signaling pathways, including the inhibition of NF-κB and STAT3 activation, and downregulation of the MAPK pathway, collectively contributing to its profound soothing and anti-allergenic effects on skin.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In vitro studies on human keratinocytes (HaCaT cells) demonstrated that Hovenia Dulcis Fruit Extract provides a preventive effect against TNF-α-induced abnormal proliferation, a hallmark of psoriatic inflammation. It significantly suppressed the expression of key inflammatory cytokines (IL-1α, IL-1β) and chemokines (CCL-20, CXCL-8), while also downregulating critical signaling pathways including phosphorylated IκB, STAT3, and MAPK, indicating its potential to alleviate skin inflammation.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The storage stability of Hovenia Dulcis Fruit Extract powder can be enhanced, and tackiness reduced, by utilizing beta-cyclodextrin as an excipient.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Hovenia Dulcis Fruit Extract is generally regarded as safe. Toxicological studies for novel food applications have indicated no acute or sub-chronic toxicity up to an indicative No Observed Adverse Effect Level (NOAEL) of 1200 mg/kg/day through oral consumption. While specific cosmetic safety assessments by CIR or SCCS are not available, the FDA typically classifies fruit extracts. Oral consumption has shown no serious adverse events in human clinical trials, though some individuals may experience mild gastrointestinal discomfort or allergic reactions.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Hovenia Dulcis Fruit Extract is a valuable botanical ingredient, offering potent antioxidant and anti-inflammatory benefits with a favorable safety and skin compatibility profile for a wide range of skin types.

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