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Moumoujus

HEXYL NICOTINATE.

Valuable CAS 23597-82-2 / ANTISTATIC, SKIN CONDITIONING - EMOLLIENT

Hexyl Nicotinate is a nicotinic acid ester primarily recognized for its mild vasodilatory action, enhancing cutaneous blood flow. It also serves as an emollient, contributing to skin softness and smoothness.

Summary

Increases blood flow (vasodilator) Emollient Antistatic Moisturizer Supports skin regeneration Helps normalize skin pH Regulates oil secretion

Science

Mechanism of Action

This ingredient penetrates the skin rapidly, inducing mild vasodilation to temporarily boost blood circulation in the skin. This mechanism facilitates improved delivery of oxygen, essential nutrients, and moisture to skin cells, concurrently accelerating the removal of metabolic waste. Beyond microcirculatory enhancement, Hexyl Nicotinate acts as an emollient, softening the skin, and an antistatic agent. It aids in revitalizing fatigued and dull skin, strengthens natural defenses against irritants, helps to normalize skin pH, and contributes to the regulation of sebaceous gland activity.

Research

Clinical Evidence

High confidence
Effective range 0.1–2%
Optimal

1%

Key findings

  1. 01 Clinical research at a 0.1% concentration demonstrated an increase in cutaneous blood flow, particularly on the forearm, in both healthy subjects and patients with Raynaud's phenomenon.
  2. 02 A 1.0% concentration was found to elicit a more significant increase in blood flow and a higher percentage of positive responses compared to 0.1% in healthy volunteers and individuals with Raynaud's phenomenon.
  3. 03 Concentrations ranging from 1-2% are conventionally employed in topical formulations such as creams and ointments for their rubefacient effects, targeting conditions like lumbago and rheumatism.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Hexyl Nicotinate exhibits stability in aqua-ethanolic solutions when maintained at 40°C and exposed to UV radiation (λ = 254 nm). Should precipitation or phase separation occur during formulation, heating or sonication can assist in achieving full dissolution.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

Generally regarded as safe for cosmetic applications, Hexyl Nicotinate may induce irritation in individuals with sensitive skin. GHS classifications, based on ECHA reports, indicate a potential for skin irritation in 53.8% of reports and serious eye irritation in 55% of reports. It is not recommended for use in food contact polymers.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Hexyl Nicotinate is a valuable active for formulations aiming to enhance skin microcirculation and vitality, although its moderate irritancy profile necessitates careful formulation, especially for sensitive skin types.

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