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Moumoujus

HEXYL BUTYRATE.

Optional CAS 2639-63-6 / PERFUMING

Hexyl Butyrate is an ester synthesized from hexanol and butyric acid, primarily utilized as a perfuming and flavoring agent. While its direct efficacy as a skincare active is not extensively documented, its constituent, butyric acid, is recognized for potential postbiotic benefits to skin health.

Summary

perfuming

Science

Mechanism of Action

As an ester, Hexyl Butyrate is linked to the potential dermatological benefits of its butyric acid component, a short-chain fatty acid. Butyric acid is understood to act as a postbiotic, potentially modulating immune responses by inhibiting the production of inflammatory cytokines and cells. It may also support the proliferation of regulatory T cells, influence the skin's microbial balance, enhance skin barrier integrity, and contribute to overall eutrophic and anti-inflammatory effects within the skin. However, the direct mechanism of action for Hexyl Butyrate itself as a primary skincare active has not been thoroughly investigated.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Hexyl Butyrate demonstrates chemical stability under standard ambient conditions (room temperature). It exhibits excellent solubility in organic solvents and maintains stability across various formulation conditions, which enhances its utility in product development.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
8%
Sensitization risk Low

The FDA lists Hexyl Butyrate as a 'FLAVORING AGENT OR ADJUVANT' under 21 CFR 172.515. The Joint FAO/WHO Expert Committee on Food Additives concluded 'No safety concern at current levels of intake when used as a flavouring agent'. The Research Institute for Fragrance Materials (RIFM) has assessed its safety as a fragrance ingredient, determining it can be safely used in everyday products at current levels, recommending a maximum usage level of 8.0000% in fragrance concentrates. A human experience study observed no irritation or sensitization with a 12% solution. However, some industrial safety data (RTECS, Sigma-Aldrich MSDS) describe it as a 'mild skin irritant,' and European information indicates it is 'Irritating to skin and eyes' (R 36/38), which may refer to concentrated forms.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Optional

Hexyl Butyrate primarily serves as a perfuming agent in skincare, with its potential benefits derived from its butyric acid component requiring more direct investigation for its active role.

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