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Moumoujus

HEXAPEPTIDE-78.

Insufficient Data / NOT REPORTED

Hexapeptide-78 is an ingredient for which available research data, primarily associated with Acetyl Hexapeptide-8, suggests a role in visibly diminishing expression lines. It is understood to modulate nerve-muscle communication, contributing to a smoother skin appearance and potentially improving moisturization.

Summary

humectant skin conditioning anti-aging anti-wrinkle

Science

Mechanism of Action

This hexapeptide, primarily studied as Acetyl Hexapeptide-8, acts by interfering with nerve-muscle communication. It achieves this by mimicking the N-terminal end of SNAP-25, competing for a position within the SNARE complex. This destabilization reduces the release of acetylcholine, a neurotransmitter crucial for muscle contraction, thereby attenuating muscle movement and relaxing expression lines. Additionally, it may support collagen production and block calcium channels in neurons.

Research

Clinical Evidence

Low confidence
Effective range 5–10%
Optimal

N/A

Key findings

  1. 01 Demonstrated a 17% reduction in wrinkle depth around the eyes within 15 days in manufacturer in-vivo tests (for Argireline solution).
  2. 02 Achieved a 16.26% decrease in wrinkle depth after 28 days in a clinical study involving 14 volunteers (for Argireline solution in a cream).
  3. 03 Research by a Spanish University indicated increased skin moisturization and significant reductions in both the depth and width of wrinkles (for Argireline).

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Acetyl Hexapeptide-8 is highly water-soluble. Its stability against enzymatic degradation and skin penetration are enhanced by N-terminal acetylation and C-terminal amidation. Permeability through skin is significantly greater in acidic conditions (e.g., pH 2.7) compared to alkaline environments (pH 7.4).

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
0.005%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel deemed Acetyl Hexapeptide-8 (including Acetyl Hexapeptide-8 Amide) safe for use in cosmetics at concentrations up to 0.005%. Data at higher concentrations were considered insufficient. It is crucial to note that this safety information, along with clinical efficacy and mechanism data, pertains to Acetyl Hexapeptide-8, as direct data for 'Hexapeptide-78' was not identified in the research.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Insufficient Data

While research on Acetyl Hexapeptide-8 indicates significant efficacy in reducing wrinkle depth and improving moisturization, direct clinical and safety data specifically for Hexapeptide-78 is currently insufficient for a definitive assessment.

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