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HEXAPEPTIDE-6.

Insufficient Data CAS - / SKIN CONDITIONING

HEXAPEPTIDE-6 is a synthetic signaling peptide designed to mimic fibronectin, a vital protein in the skin's extracellular matrix. It aims to activate the skin's natural repair mechanisms, contributing to enhanced smoothness and a more even complexion.

Skin conditioning

Science

This hexapeptide operates by signaling to the skin's endogenous repair pathways, stimulating the regeneration of mature skin cells. By mimicking fibronectin, it reinforces cellular adhesion and increases integrin expression, thereby strengthening skin structure. This action supports the visible reduction of wrinkles, improvement of complexion, and enhancement of elasticity.


Research

Low confidence
Effective range 0.5–3%
Optimal

N/A


Transparency

Not commonly dusted

Current research data does not suggest that HEXAPEPTIDE-6 is typically used at concentrations considered to be 'dusting,' where efficacy is negligible.


The Formula

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

This fibronectin-like hexapeptide exhibits an affinity for forming complex ions with alkali metals, with the strongest affinity observed for sodium. This characteristic is an important consideration for formulators to ensure product stability and ingredient efficacy.


Safety

CIR Status
Not reviewed
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) Expert Panel has not conducted a specific safety assessment for HEXAPEPTIDE-6. While other distinct hexapeptides, such as Acetyl Hexapeptide-8 Amide and Palmitoyl Hexapeptide-12, have been reviewed, their safety conclusions are not applicable to HEXAPEPTIDE-6.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Insufficient Data

While early studies indicate potential benefits for skin smoothness and complexion, more comprehensive clinical trials and a formal safety review are necessary for a definitive assessment of HEXAPEPTIDE-6.


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