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Moumoujus

HEXAPEPTIDE-52.

Valuable / SKIN CONDITIONING

Palmitoyl Hexapeptide-52 is a synthetic lipopeptide recognized for its neuro-relaxing properties, effectively minimizing the appearance of expression lines and wrinkles. It functions by temporarily inhibiting muscle contractions, offering a smoothing effect on the skin while also stimulating natural regeneration processes.

Summary

anti-aging skin conditioning moisturizing evens skin tone

Science

Mechanism of Action

This synthetic lipopeptide operates by a 'Botox-like' mechanism, preventing neuronal cells from signaling muscles to contract. Specifically, it inhibits the release of acetylcholine into the synaptic cleft by blocking calcium entry into neurons, thereby relaxing expression muscles. Beyond this, as a peptide, it also signals the skin to activate endogenous repair mechanisms, promoting regeneration, strengthening skin structure, and further reducing the visibility of wrinkles.

Research

Clinical Evidence

High confidence
Effective range 0.001–3%
Optimal

N/A

Key findings

  1. 01 At a concentration of 0.001%, when integrated into an intelligent targeting system (X50® Myocept), this peptide has demonstrated a 20% reduction in both the depth and length of wrinkles.
  2. 02 In another study, a 3% concentration of HEXAPEPTIDE-52 (as part of a 5% total peptide blend) significantly diminished the appearance of fine lines, wrinkle depth, and expression lines. 95% of participants experienced a notable reduction in these visible signs of aging after just 4 weeks.

Transparency

Dusting Analysis

Not commonly dusted
Min. effective
0.001%

Clinical evidence indicates HEXAPEPTIDE-52 begins to show significant efficacy at concentrations as low as 0.001%, particularly when delivered through advanced targeting systems. Efficacy is also observed at higher concentrations, such as 3% within a peptide blend. This robust performance at minimal percentages suggests it is not typically 'dusted' in formulations.

The Formula

Formulation

Solubility
Both
Optimal pH 7 – 7
0 7 14

Stability

Analogous palmitoylated hexapeptides maintain chemical integrity at pH levels around 7, with no significant degradation reported under normal temperature and light exposure.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Specific safety assessments by CIR, SCCS, or FDA for Palmitoyl Hexapeptide-52 are currently unavailable. The Environmental Working Group (EWG) has rated it as having low concern for allergies, immunotoxicity, and developmental/reproductive toxicity. Side effects are rare, generally limited to mild irritation or allergic reactions in individuals with highly sensitive skin. A general discussion by CIR regarding 'palmitoyl oligopeptide ingredients' noted a need for further information on amino acid sequences, but this was not specific to Palmitoyl Hexapeptide-52.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

HEXAPEPTIDE-52 is a valuable neuro-relaxing peptide that effectively reduces expression lines and wrinkles with clinically proven results, exhibiting broad skin compatibility and a low risk of irritation.

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