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Moumoujus

HEXAPEPTIDE-5.

Insufficient Data CAS - / SKIN CONDITIONING

Hexapeptide-5, also known as Acetyl sh-Hexapeptide-5 Amide Acetate, is a sophisticated peptide designed to enhance skin firmness, elasticity, and overall structural integrity. It actively reinforces skin ligaments and safeguards against degradation, promoting a visibly lifted and smoother complexion. This multi-functional ingredient also provides hydration, mimicking the effects of hyaluronic acid to maintain balanced moisture levels.

Summary

Skin Conditioning Anti-aging Firming Hydrating Elasticity Enhancer

Science

Mechanism of Action

This hexapeptide operates by bolstering the skin's inherent support structures. It specifically promotes the formation of the fibrillin-versican-hyaluronic acid complex, which is crucial for strengthening skin ligaments and improving skin cohesion and tautness. Furthermore, Hexapeptide-5 actively prevents the breakdown of elastin by inhibiting key degrading enzymes, elastase and metalloproteinases 1 and 3. Concurrently, it stimulates the synthesis and proper assembly of tropoelastin, hyaluronic acid, and other vital extracellular matrix components, which collectively improve the skin's viscoelasticity, volume, and flexibility. As a signaling peptide, it supports the skin's intrinsic repair and regeneration processes.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

No specific information regarding 'dusting' or ineffective concentrations for Hexapeptide-5 is available in the research data. The ingredient's complex mechanism suggests efficacy is likely concentration-dependent, but precise figures are not provided.

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

Hexapeptide-5 is synthesized as Acetyl sh-Hexapeptide-5 Amide Acetate, an acetate salt form designed to optimize its stability and effectiveness in skincare preparations. As with many peptides, its stability can be compromised by factors such as extreme pH levels, exposure to oxygen, presence of metal ions, and light. Formulators can mitigate these issues by carefully adjusting pH, minimizing oxygen exposure, protecting from light, and incorporating antioxidants or metal chelators.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) has not independently assessed Hexapeptide-5. Similarly, there is no specific opinion from the SCCS or status from the FDA. However, validated supplier testing indicates that Acetyl sh-Hexapeptide-5 Amide Acetate is non-irritating and non-sensitizing in typical cosmetic applications.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Insufficient Data

Hexapeptide-5 presents a highly promising mechanism for skin firming, elasticity, and hydration, with a favorable safety profile based on supplier data, but further independent clinical studies detailing effective concentrations and quantifiable outcomes are needed for a definitive efficacy rating.

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