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Moumoujus

HEXAPEPTIDE-49.

Valuable / SKIN CONDITIONING

HEXAPEPTIDE-49, primarily utilized as Acetyl Hexapeptide-49, is a precision biomimetic peptide engineered to soothe reactive skin and reinforce barrier integrity. It targets neurogenic inflammation to mitigate discomfort, enhance hydration, and facilitate skin repair mechanisms.

Summary

skin conditioning anti-inflammatory soothing hydrating barrier repair

Science

Mechanism of Action

This peptide functions by precisely modulating the activity of Proteinase-activated receptor 2 (PAR-2), a key receptor found in epidermal keratinocytes that governs inflammatory responses. By inhibiting PAR-2, Acetyl Hexapeptide-49 significantly reduces the production of pro-inflammatory cytokines such as IL-6 (up to 69.6%) and IL-8 (71.5%), effectively calming neurogenic inflammation. Its action extends to nerve endings, alleviating sensations of itching, stinging, burning, and tightness. Furthermore, it promotes cell proliferation and differentiation to support skin barrier repair, improves skin hydration, and offers a degree of photoprotection by enhancing cell viability post-UV exposure.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Clinical studies on Delisens™ complex, which contains Acetyl Hexapeptide-49, demonstrated a 34% increase in skin hydration and a 32% reduction in tingling sensation within one week of application.
  2. 02 Further data indicated that this complex reduced Proteinase-activated receptor 2 (PAR-2) activity by up to 80% and significantly diminished the production of key pro-inflammatory cytokines, specifically IL-6 by up to 69.6% and IL-8 by 71.5%.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Acetylation notably enhances the stability and efficacy of Hexapeptide-49. It is well-suited for integration into emulsions, gels, essences, and masks, provided that moderate processing temperatures are maintained to preserve its peptide integrity. The ingredient has shown effectiveness even following concentrated AHA treatments. Stock solutions should be aliquoted into tightly sealed vials, stored appropriately, and utilized within one month, strictly avoiding repeated freeze-thaw cycles.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Acetyl Hexapeptide-49 is broadly considered safe for topical application in cosmetic products, demonstrating high tolerability, especially for sensitive or reactive skin types. It is categorized as non-irritating and non-sensitizing. While adverse reactions like irritation or allergic responses are uncommon, a patch test is recommended. Specific data regarding its use during pregnancy and breastfeeding is currently insufficient, hence consulting a healthcare professional is advisable.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

HEXAPEPTIDE-49 is a valuable biomimetic peptide demonstrating significant efficacy in calming neurogenic inflammation, enhancing skin hydration, and supporting barrier repair, making it highly beneficial for sensitive and reactive skin types.

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