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Moumoujus

HEXAPEPTIDE-43.

Valuable / SKIN CONDITIONING

HEXAPEPTIDE-43 is a specialized biomimetic peptide engineered to address neurogenic inflammation in sensitive skin. It effectively mitigates discomfort, itching, and pain, while simultaneously promoting the repair of damaged tissue and enhancing skin hydration.

Summary

Anti-inflammatory Soothing Skin Repair Hydrating Pain Relief Itch Reduction

Science

Mechanism of Action

This hexapeptide operates by down-regulating the activity of Protease-Activated Receptor 2 (PAR-2) within skin cells. This crucial action reduces the release of inflammatory neuropeptides and cytokines, specifically Calcitonin Gene-Related Peptide (CRGP), Interleukin-6 (IL-6), and Interleukin-8 (IL-8). By modulating these pathways, HEXAPEPTIDE-43 effectively calms neurogenic inflammation, alleviating pain, discomfort, and itching. Additionally, it supports the integrity of damaged tissue through re-epithelization and contributes to overall skin hydration.

Research

Clinical Evidence

Medium confidence
Effective range 2–5%
Optimal

N/A

Key findings

  1. 01 A clinical investigation published in Cosmetics & Toiletries highlighted that HEXAPEPTIDE-43, at concentrations between 2% and 5%, demonstrated significant efficacy in reducing neurogenic inflammation, associated pain, discomfort, and itching in sensitive skin. The study also reported improvements in damaged tissue integrity, facilitating re-epithelization and repair, alongside enhanced hydration, resulting in smoother and softer skin.

Transparency

Dusting Analysis

Not commonly dusted

No data available regarding 'dusting' potential or common low-concentration uses for HEXAPEPTIDE-43.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The hexapeptide solution exhibits water solubility and is also soluble in glycols, suggesting good compatibility in various aqueous formulations.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Current regulatory bodies, including CIR, SCCS, and FDA, have not yet reviewed HEXAPEPTIDE-43. It is important to note that safety data pertaining to other hexapeptides cannot be definitively extrapolated to this specific compound, indicating a need for dedicated assessments.

Your Skin

Skin Compatibility

No Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Hexapeptide-43 is a valuable active ingredient for sensitive and dry skin, effectively mitigating neurogenic inflammation and supporting skin barrier repair and hydration, though comprehensive safety data is currently limited.

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References

Sources