Science
Mechanism of Action
Operating as a signal peptide, Hexapeptide-42 orchestrates epidermal differentiation and barrier biology. It precisely activates Caspase-14, a proteolytic enzyme integral to Filaggrin metabolism. The resultant Filaggrin metabolites act as Natural Moisturizing Factors (NMFs), critically enhancing dermal hydration. Furthermore, Hexapeptide-42 safeguards DNA integrity by preventing UVB-induced damage, stimulating intrinsic repair mechanisms, and promoting optimal cornification. It also supports mitochondrial function, protecting mitochondrial DNA, and provides anti-photoaging benefits through stratum corneum optimization. This peptide is also instrumental in promoting extracellular matrix (ECM) renewal, fostering synthesis of Type I and III collagen, and elevating elastin fiber density, thereby improving skin elasticity, texture, and overall resilience.
Research
Clinical Evidence
Medium confidence0.5%
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Hexapeptide-42 exhibits robust stability within diverse formulations, simplifying its integration into skincare products.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) has not issued a specific safety assessment for Hexapeptide-42 (Caspaline 14). While its low irritancy profile is noted and other hexapeptides have demonstrated safety at low concentrations, this cannot be directly extrapolated without a specific review for Hexapeptide-42.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Hexapeptide-42 is a valuable, multi-functional signal peptide capable of significantly improving skin hydration, barrier integrity, and combating visible signs of aging through its targeted biological actions.
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