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Moumoujus

HEXAPEPTIDE-40 SH-OLIGOPEPTIDE-1.

Insufficient Data / SKIN CONDITIONING

HEXAPEPTIDE-40 SH-OLIGOPEPTIDE-1 is a sophisticated fusion peptide engineered to activate the skin's inherent repair mechanisms by interacting with key cellular receptors. It aims to fortify the skin's structural integrity by boosting critical substances like collagen, elastin, and hyaluronic acid, thereby addressing visible signs of aging. Despite its proposed bioequivalence to Epidermal Growth Factor (EGF), its functional efficacy in cosmetic applications is currently a subject of ongoing scientific discourse.

Summary

Skin-identical ingredient Cell-communicating ingredient

Science

Mechanism of Action

This fusion peptide operates by acting as a cell-communicating ingredient, sending precise signals from the skin's surface to specific receptor sites. This process is intended to inspire the skin's natural repair and regenerative pathways, encouraging the synthesis of essential dermal components such as collagen, elastin, and hyaluronic acid. Such activity is hypothesized to contribute to measurable reductions in wrinkle depth, width, and volume, and to enhance overall skin firmness. It is considered a bioequivalent to Epidermal Growth Factor (EGF), a known cellular signaling molecule that can stimulate cell growth and differentiation; however, its practical efficacy as an EGF mimetic in cosmetic formulations requires further conclusive scientific validation.

Research

Clinical Evidence

Low confidence
Effective range 1–2%
Optimal

N/A

Key findings

  1. 01 Clinical observations indicate that when HEXAPEPTIDE-40 SH-OLIGOPEPTIDE-1 is incorporated into a water-based blend at concentrations between 1% and 2%, it can demonstrably reduce the depth, width, and volume of wrinkles. However, the scientific community has raised questions regarding the fundamental scientific basis and the proven preclinical bioactivity of sh-oligopeptide-1 (its EGF bioequivalent component), suggesting a need for more robust evidence to support these claims.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

This ingredient is typically supplied within a water-based blend, suggesting this format is optimal for its stability and functional integrity within a formulation.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) has not provided a specific assessment for this exact ingredient, resulting in an 'insufficient data' status. While peptides generally fall under the FDA's 'Generally Recognized as Safe' (GRAS) category, sh-oligopeptide-1 is approved for use in cosmetics at various concentrations. However, comprehensive data on its long-term systemic risks and safety profile remain unavailable.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While some studies indicate a potential for wrinkle reduction, the overall scientific validation of HEXAPEPTIDE-40 SH-OLIGOPEPTIDE-1 as an EGF bioequivalent and its long-term safety profile are currently subject to significant debate and insufficient data, warranting cautious consideration.

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