Science
Mechanism of Action
This innovative peptide, also known as Acetyl Hexapeptide-37 or Diffuporine™, functions by upregulating Aquaporin-3 (AQP3) expression within keratinocytes. AQP3 channels are critical for facilitating efficient water movement through cell membranes, thus enhancing water distribution from deeper skin layers to the stratum corneum. This mechanism not only boosts hydration but also supports keratinocyte viability and barrier function. Furthermore, it contributes to anti-aging by promoting keratinocyte proliferation, reducing transepidermal water loss, and stimulating dermal fibroblasts to increase Type I collagen production, leading to visibly smoother, firmer, and more elastic skin.
Research
Clinical Evidence
High confidenceN/A
Transparency
Dusting Analysis
Hexapeptide-37 is clinically effective at very low concentrations, with recommended cosmetic formulation levels between 0.001% and 0.005%. Formulations containing concentrations significantly below this range, such as 0.0005% or less, are unlikely to deliver its full intended benefits for hydration and anti-aging.
The Formula
Formulation
Stability
Stock solutions demonstrate stability for 6 months when stored at -80°C, and for 1 month at -20°C, provided they are sealed and protected from moisture.
Safety
Safety Profile
While Acetyl Hexapeptide-37 itself lacks a direct CIR safety assessment, the CIR Panel has evaluated the related Acetyl Hexapeptide-8 Amide, concluding its safety at concentrations up to 0.005%. SkinSAFE lists Hexapeptide-37 as 'Irritant Free', 'Dye Free', 'Lanolin Free', 'Soy Free', and 'Teen Safe', indicating a favorable safety profile across various skin sensitivities.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Hexapeptide-37 is a valuable ingredient for advanced hydration and anti-aging formulations, offering clinically supported improvements in skin moisture and barrier integrity through its unique Aquaporin-3 boosting mechanism.
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