Science
Mechanism of Action
This synthetic hexapeptide, specifically as Ferric Hexapeptide-35, forms a complex with Fe3+ ions, thereby emulating the function of the skin's natural peroxidase enzymes. This enzymatic activity is crucial for detoxifying the skin by breaking down harmful peroxyl radicals and reactive oxygen species (ROS), which are major contributors to cellular degradation and premature aging. It offers multifaceted protection by safeguarding DNA from radical damage, diminishing lipid peroxidation, and reducing protein degeneration. Furthermore, its action helps to sustain physiological levels of autophagy and proteasome activity, essential cellular processes for regeneration and maintaining skin youthfulness.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
As a peptide, HEXAPEPTIDE-35 is inherently water-soluble. However, precise optimal pH ranges for its stability in cosmetic formulations have not been specifically documented in the available research.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel, SCCS, and FDA have not conducted specific safety assessments for HEXAPEPTIDE-35 (or Ferric Hexapeptide-35). However, other hexapeptides, such as Tripeptide-1 and Hexapeptide-12, have been deemed safe for cosmetic use at typical concentrations, generally below 10 ppm.
Your Skin
Skin Compatibility
Our Assessment
Verdict
HEXAPEPTIDE-35 presents a promising mechanism as an antioxidant and anti-aging peptide through its enzymatic detoxifying activity, though comprehensive clinical efficacy data and specific safety assessments are currently unavailable.
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References
Sources