Science
Mechanism of Action
This hexapeptide acts as a potent antioxidant and reducing agent, safeguarding other ingredients from oxidative deterioration. More significantly, it functions as a skin-protecting signal, prompting the skin's inherent repair mechanisms to activate, thereby contributing to protein synthesis crucial for skin integrity.
Research
Clinical Evidence
Medium confidence0.025%
Key findings
- 01 A hexapeptide solution at 0.025% active concentration was observed to significantly reduce the release of neurogenic inflammation markers (CRGP, IL-6, and IL-8) from skin cells. This action effectively mitigated pain, discomfort, and itching associated with sensitive skin. Furthermore, it supported the restoration of damaged tissue integrity, facilitating re-epithelization and repair, and improved hydration in dry skin, leading to a smoother and softer texture.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
While no specific optimal pH range for Hexapeptide-22 stability was identified, related peptides like Acetyl Hexapeptide-8 have shown improved skin permeability in acidic conditions (pH 2.7) compared to alkaline (pH 7.4), and are typically formulated in aqueous blends around pH 5.5 ± 0.2.
Safety
Safety Profile
Specific safety assessments by CIR, SCCS, or FDA for Acetyl Hexapeptide-22 are not available. It is distinct from Acetyl Hexapeptide-8, for which CIR reports exist. Due to the lack of specific data, its irritancy and comedogenicity are currently unknown.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Hexapeptide-22 is a valuable ingredient, demonstrating significant benefits in reducing neurogenic inflammation, aiding skin repair, and improving hydration across all skin types.
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