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Moumoujus

HEXAPEPTIDE-20.

Valuable CAS - / SKIN CONDITIONING

Hexapeptide-20 is a precision peptide engineered to counteract visible signs of aging by targeting enzymatic degradation pathways and reinforcing the skin's moisture barrier. It is designed to promote a firmer, more elastic, and youthful skin appearance while supporting overall skin health.

Summary

Skin-Restoring Cell-communicating ingredient Anti-aging Firming Agent Elasticity Enhancer Hydration Support Barrier Reinforcement

Science

Mechanism of Action

This peptide primarily functions by inhibiting matrix metalloproteases (MMPs), which are enzymes responsible for breaking down crucial extracellular matrix proteins like collagen and elastin. By mitigating MMP activity, Hexapeptide-20 helps restore the balance between protein synthesis and degradation, leading to an increase in collagen and elastin levels within the skin. Concurrently, it reduces trans-epidermal water loss (TEWL), thereby enhancing skin volume, elasticity, and overall density. It also supports the skin's natural repair processes and protects against both chronological aging and environmental photoaging.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Demonstrates inhibition of matrix metalloproteases (MMPs), leading to increased collagen and elastin.
  2. 02 Reduces trans-epidermal water loss (TEWL), thereby enhancing skin volume, elasticity, and density.
  3. 03 Associated with the prevention of chronological aging and photoaging, resulting in firmer, more supple skin.
  4. 04 Exhibits specific benefits for men's skin, including MMP inhibition and TEWL reduction, addressing high testosterone-related barrier impairment.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

Peptides are generally susceptible to enzymatic degradation. While specific data for Hexapeptide-20 is not available, related hexapeptides indicate improved solubility and skin permeation in acidic environments (e.g., pH 2.7 vs 7.4), suggesting formulators may consider pH optimization for enhanced stability and bioavailability.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While the Cosmetic Ingredient Review (CIR) Expert Panel has not specifically reviewed Hexapeptide-20, related hexapeptides have been assessed. SkinSAFE classifies Hexapeptide-20 as 'Irritant Free', 'Fragrance Free', 'Paraben Free', 'Dye Free', 'SLS Free', 'Teen SAFE', 'Lip SAFE', 'Baby SAFE', and 'Eyelid SAFE', indicating a highly favorable safety profile across various applications.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Hexapeptide-20 is a valuable ingredient for advanced anti-aging and skin barrier support, specifically beneficial for mitigating collagen degradation and enhancing skin hydration and density.

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