Science
Mechanism of Action
Functioning as a biomimetic signaling molecule, HEXAPEPTIDE-13 stimulates the synthesis of extracellular matrix proteins, which are vital components of skin structure. It enhances adhesion between skin cells and promotes increased integrin expression, thereby delivering essential signals for comprehensive skin repair. This cascade of actions collectively improves skin appearance and targets various symptoms associated with skin aging, leveraging peptides' broader roles in processes like cell migration, proliferation, and protein regulation.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 While specific human clinical trials for HEXAPEPTIDE-13 are not extensively detailed in the available data, in vivo research on a hexapeptide characterized by the sequence ALA-ASP-LEU-LYS-PRO-THR demonstrates its capacity to stimulate extracellular matrix protein synthesis, enhance cellular adhesion, and increase integrin expression. This provides signals crucial for skin repair, contributing to improved skin appearance and addressing signs of aging.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Optimal pH ranges for the stability of HEXAPEPTIDE-13 specifically are not provided. However, related hexapeptides such as Acetyl Hexapeptide-3 (Acetate) demonstrate solubility in aqueous buffers at pH 7.2. For Acetyl Hexapeptide-8, skin permeability has been observed to be significantly higher in acidic environments compared to alkaline, suggesting that pH can influence the stability or efficacy of this peptide class.
Safety
Safety Profile
Specific safety assessments for HEXAPEPTIDE-13 by major regulatory bodies such as the Cosmetic Ingredient Review (CIR), SCCS, or FDA have not been identified. It is noted that the CIR has reviewed other hexapeptides, including Hexapeptide-12 and Acetyl Hexapeptide-8, providing some context for the peptide class but not specific to HEXAPEPTIDE-13.
Your Skin
Skin Compatibility
Our Assessment
Verdict
HEXAPEPTIDE-13 emerges as a valuable signaling peptide, demonstrating a strong mechanistic basis and preliminary in vivo evidence for its role in promoting skin repair and mitigating signs of aging, although comprehensive specific clinical and safety data would further solidify its profile.
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References
Sources