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Moumoujus

HEXAPEPTIDE-1.

Valuable CAS - / SKIN CONDITIONING

HEXAPEPTIDE-1, often specifically studied as Acetyl Hexapeptide-1, is a multi-functional biomimetic peptide engineered to address multiple signs of skin aging and environmental damage. It works to rejuvenate skin by boosting essential structural proteins, offering antioxidant defense, and enhancing the skin's natural protective functions, including unique melanin-related photoprotection.

Summary

Skin-identical ingredient Antioxidant Skin-conditioning Humectant UV Filter

Science

Mechanism of Action

Research indicates that Acetyl Hexapeptide-1, a biomimetic peptide, functions by signaling skin cells to boost natural biological processes. It stimulates fibroblasts to increase collagen and elastin synthesis, thereby improving skin structure and resilience. As an antioxidant, it effectively reduces free radical damage. Furthermore, it fortifies the skin barrier, minimizing transepidermal water loss, and enhances photoprotection by repairing UV-induced DNA damage and reducing erythema and inflammation. A notable aspect of its mechanism involves interaction with the MC1R receptor, promoting melanin production and transfer, which can result in tanning and added protection against UV-induced harm and redness. The peptide also possesses anti-inflammatory properties, alleviating redness in sensitive skin.

Research

Clinical Evidence

Medium confidence
Effective range 0.02–0.02%
Optimal

0.02%

Transparency

Dusting Analysis

Not commonly dusted

No data regarding common 'dusting' practices or specific dusting thresholds for Hexapeptide-1 is available in the provided research.

The Formula

Formulation

Solubility
Water
Optimal pH 4.5 – 6.5
0 7 14

Stability

Water-soluble, suitable for addition to the water phase or cooling phase of a formulation. Exhibits good heat stability, contributing to a 12-month shelf life.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Dermatologically tested and generally considered safe, presenting a low risk of irritation and sensitivity. It is described as hypoallergenic and well-suited for most skin types, including sensitive skin. Moumoujus recommends patch testing before widespread use, particularly when integrating into new formulations, and suggests usage in low concentrations. A formal CIR review specifically for Hexapeptide-1 is not yet available, distinct from other hexapeptides like Hexapeptide-8 or Hexapeptide-12.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

HEXAPEPTIDE-1 is a valuable multi-functional peptide that effectively targets photoaging, boosts collagen, offers antioxidant protection, and uniquely supports skin's natural photoprotection and barrier function across all skin types with a low risk of irritation.

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