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HEXAMIDINE DIISETHIONATE.

Valuable CAS 659-40-5 / ANTI-SEBORRHEIC, ANTIMICROBIAL, PRESERVATIVE

Hexamidine Diisethionate is a versatile polycationic compound celebrated for its potent, broad-spectrum antimicrobial action against various skin microorganisms, including those linked to acne and dandruff. Beyond its antiseptic capabilities, it offers anti-inflammatory benefits to soothe irritation and redness, while also serving as an effective cosmetic preservative.

Summary

Antiseptic Preservative Biocide Anti-inflammatory Skin Conditioning Antifoaming Emollient

Science

Mechanism of Action

This ingredient primarily acts through its potent antimicrobial properties, effectively reducing a wide array of bacteria and fungi on the skin's surface. It also exhibits anti-inflammatory effects, which contribute to soothing skin irritations, redness, and swelling, potentially by inhibiting serine proteases associated with inflammatory responses. Furthermore, it supports the skin's barrier function and acts as a broad-spectrum preservative within cosmetic formulations.

Research

Clinical Evidence

High confidence
Effective range 0.03–0.1%
Optimal

0.1%

Key findings

  1. 01 At 0.10%, it functions as an effective antiseptic for topical applications, demonstrating utility in addressing concerns like acne, seborrheic conditions (pityrosporoses), and scalp dandruff.
  2. 02 Clinical trials involving 200 human subjects showed that a 0.10% concentration did not induce primary irritation, inflammation, or sensitization.
  3. 03 In a patch test with 100 human subjects, a 0.1% concentration in aqueous solution or cold cream produced no signs of irritation, inflammation, or sensitization.
  4. 04 A 0.1% solution in 30% alcohol significantly reduced bacterial flora by 70% to 90% on the antecubital fossa of 20 healthy volunteers.
  5. 05 It functions as a biocide in cosmetics at concentrations between 0.03% and 0.1%.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 6.5
0 7 14

Stability

Exhibits good solubility in water and alcohol but is insoluble in organic solvents. The compound remains stable and effective under typical storage conditions, including exposure to light and heat. Its optimal antimicrobial activity spans a pH range of 5 to 9, and it generally displays good compatibility without being prone to color change.

Conflicts

  • Chloride ions
  • Sulfate ions
  • Some proteins

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
0.1%
Sensitization risk Low

The CIR Expert Panel and SCCS have deemed Hexamidine Diisethionate safe for cosmetic use at concentrations not exceeding 0.1%, a conclusion reaffirmed in 2022. While generally well-tolerated, rare instances of allergic contact dermatitis have been documented, particularly among individuals with atopic skin conditions, though overall sensitization is uncommon. Formulators must ensure purification steps minimize 1,4-dioxane impurities. Specific data is lacking for unrestricted use in eye makeup and baby products, warranting caution in these categories.

Your Skin

Skin Compatibility

Yes Normal
No Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Hexamidine Diisethionate is a valuable multi-functional ingredient, offering proven antimicrobial and anti-inflammatory benefits within a well-defined and safe concentration limit of 0.1% for various skin concerns and product types.

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