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Moumoujus

HEXAHYDRO-TETRAMETHYL-METHANONAPHTHALENE.

Optional CAS 1135-66-6 / PERFUMING

This ingredient functions primarily as a fragrance agent in cosmetic formulations, contributing a specific aromatic profile. While direct data on its specific skin benefits is limited, structurally related compounds, Hexahydro-β-acids (HBA), have demonstrated anti-inflammatory and potential anti-tumor properties in murine models. It exhibits oil solubility, making it suitable for integration into various formulation types.

Summary

Fragrance

Science

Mechanism of Action

The primary mechanism of HEXAHYDRO-TETRAMETHYL-METHANONAPHTHALENE on the skin is to impart a scent. For structurally analogous compounds like Hexahydro-β-acids (HBA), documented mechanisms include the suppression of inflammatory gene expression (specifically iNOS, COX-2, and ODC). This suppression occurs via interference with key cellular signaling pathways, including mitogen-activated protein kinases (MAPKs), phosphatidylinositol 3-kinase (PI3K)/Akt signaling, and NF-κB activation, contributing to anti-inflammatory effects. These specific mechanistic insights are derived from studies on related HBA compounds.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In murine models, structurally related Hexahydro-β-acids (HBA), at concentrations of 1 and 10 μg applied to mouse skin, significantly reduced ear edema, epidermal hyperplasia, and infiltration of inflammatory cells induced by TPA. Furthermore, these HBAs suppressed the protein and gene expression of iNOS, COX-2, and ODC, and inhibited TPA-induced skin tumor formation.

Transparency

Dusting Analysis

Not commonly dusted

This ingredient is predominantly recognized for its aromatic properties as a fragrance. There is insufficient direct clinical evidence pertaining to this specific compound to warrant its consideration for efficacy-based 'dusting' in precision skincare, as any observed benefits originate from related compounds in animal studies.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Specific data on the optimal pH range for stability of HEXAHYDRO-TETRAMETHYL-METHANONAPHTHALENE is not directly available. However, related compounds generally exhibit very low water solubility, ranging from approximately 0.5648 mg/L to 18.94 mg/L at 25 °C, which is indicative of oil solubility.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) Expert Panel has not directly reviewed HEXAHYDRO-TETRAMETHYL-METHANONAPHTHALENE. While several related Hexahydro-Tetramethyl-Methanonaphthalene derivatives are listed as fragrance agents with 'None found' or 'does not meet GHS hazard criteria' in aggregated GHS information, suggesting a low acute hazard, a comprehensive safety assessment specifically for this compound, particularly regarding sensitization potential, is not available from direct reviews. An IFRA recommendation for Hexahydrotetramethyl methanonaphthalen-8-one, a similar compound, allows for usage levels up to 8.0000% in fragrance concentrates.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Optional

Primarily serving as a fragrance component, this ingredient lacks direct human efficacy data and a comprehensive safety review, positioning its inclusion as optional based on aesthetic formulation preferences rather than targeted skin benefits.

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