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Moumoujus

HEXADIENYL ISOBUTYRATE.

Questionable CAS 16491-24-0 / PERFUMING

Hexadienyl Isobutyrate is an organic ester primarily employed as a fragrance and flavoring agent. It imparts distinct fruity and green notes to formulations, but current research indicates no specific direct mechanisms of action for skincare benefits.

Summary

Fragrance Flavoring Agent

Science

Mechanism of Action

This ingredient functions principally as an aromatic compound, providing a desirable sensory experience through its fruity, green, apple, pear, and pineapple notes. There is no identified mechanism through which Hexadienyl Isobutyrate directly contributes to active skincare benefits on the skin.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

As Hexadienyl Isobutyrate primarily serves as a fragrance ingredient without identified active skincare properties, it is not an ingredient subject to 'dusting' or overestimation of dermatological benefits.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Hexadienyl Isobutyrate, particularly its cis-3-Hexenyl isomer, exhibits instability in formulations with extreme pH, such as shower gels and shampoos, due to its susceptibility to ester hydrolysis. Oxidation can be mitigated by including a trace amount of an antioxidant, such as 0.1% alpha tocopherol.

Conflicts

  • Alkaline environments
  • Acidic environments

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

The Cosmetic Ingredient Review (CIR) Expert Panel has not specifically evaluated Hexadienyl Isobutyrate or its common isomers. While the Research Institute for Fragrance Materials (RIFM) concludes 2,4-Hexadienyl Isobutyrate (CAS 16491-24-0) does not pose a skin sensitization concern at current use levels, its isomer cis-3-Hexenyl Isobutyrate (CAS 41519-23-7) is considered a skin sensitizer with a No Expected Sensitization Induction Level (NESIL) of 1000 μg/cm². The Scientific Committee on Consumer Safety (SCCS) has not published an opinion. 2,4-Hexadienyl Isobutyrate holds Generally Recognized As Safe (GRAS) status with the FDA for flavoring applications.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

Primarily serving as a fragrance agent with no identified skincare benefits, Hexadienyl Isobutyrate's use is questionable due to potential sensitization from certain isomers and a lack of specific comprehensive safety reviews for the ingredient itself.

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