Science
Mechanism of Action
This extract functions by influencing gene expression to downregulate pro-inflammatory pathways. Its active compounds are believed to act as regulators, significantly decreasing the secretion of inflammatory cytokines such as IL-2 and TNF-α, thereby mitigating inflammatory responses.
Research
Clinical Evidence
Medium confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
As with many plant extracts, active compounds like polyphenols can exhibit low stability and sensitivity to light and heat, which may limit cosmetic applications. Research is ongoing to develop more stable derivatives or utilize encapsulation technologies to enhance product longevity and efficacy.
Safety
Safety Profile
Acute oral toxicity studies in mice showed a NOAEL of 5 g/kg. Sub-chronic oral administration in rats at very high doses (4 g/kg daily for 90 days) indicated potential liver and kidney toxicity, manifested by increased serum liver enzymes and creatinine. These findings are associated with extreme oral dosages; health risks or side effects have not been recorded following proper administration of designated therapeutic dosages, and in vitro cellular safety was confirmed at efficacious concentrations for topical application.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Herniaria Glabra Extract is a valuable botanical ingredient, demonstrating promising in vitro anti-inflammatory and antioxidant capabilities, making it particularly beneficial for soothing sensitive and normal skin.
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References
Sources