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Moumoujus

HEPTAPEPTIDE-51.

Valuable / NOT REPORTED

Acetyl Hexapeptide-51 Amide, often referred to as HEPTAPEPTIDE-51, is a sophisticated synthetic peptide engineered to enhance skin's resilience against daily environmental stressors. It specifically targets cellular DNA, providing protective benefits, promoting longevity, and actively delaying the visible markers of skin aging.

Summary

Skin-conditioning Anti-aging DNA repair Photoprotection Rejuvenating Cellular longevity

Science

Mechanism of Action

This advanced synthetic peptide operates by mimicking the activity of FOXO3a, a critical transcription factor responsible for regulating the cellular response to genetic damage. By stimulating natural mechanisms to prevent errors during DNA replication, HEPTAPEPTIDE-51 contributes to genomic stability and extends cellular vitality. It adeptly shields DNA from harm, activates the skin's intrinsic repair systems, and fosters cellular longevity, proving particularly effective against stressors such as UV exposure and environmental pollutants. Furthermore, it aids in reverting cellular senescence and modulates fibroblast activity to sustain long-term skin resilience.

Research

Clinical Evidence

Medium confidence
Effective range 3–10%
Optimal

3%

Key findings

  1. 01 A manufacturer study reported a 13.7% reduction in genetic damage induced by UV radiation in the nuclei of human epidermal cells within 6 hours.
  2. 02 Another manufacturer study demonstrated a significant protective effect, increasing the cell viability of human dermal fibroblasts (HDFA) exposed to irradiation by 35.1% compared to untreated irradiated cells.
  3. 03 UV-mediated DNA damage was observed to diminish by 16.6% over a 24-hour period.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 4 – 7
0 7 14

Stability

The peptide maintains stability between pH 4 and 7, and at room temperature for at least 12 months when stored dry. It is sensitive to moisture, requiring careful storage, and must be reconstituted in aqueous or hydroalcoholic solutions if supplied as a lyophilized powder.

Conflicts

  • Potential pH conflicts with highly acidic or alkaline ingredients such as Vitamin C or retinol. To maintain efficacy, stagger application or utilize separate formulations.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

No specific safety assessments from CIR, SCCS, or FDA have been identified for Acetyl Hexapeptide-51 Amide. Side effects and adverse reactions are reported as relatively uncommon, though a patch test is recommended before widespread usage. Data regarding topical application during pregnancy and breastfeeding are insufficient, necessitating consultation with a healthcare professional.

Your Skin

Skin Compatibility

Yes Normal
No Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

HEPTAPEPTIDE-51 is a valuable, precision-focused ingredient, offering targeted DNA protection and anti-aging benefits with a low risk of irritation, making it highly suitable for a broad spectrum of skin types seeking cellular resilience.

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