Science
Mechanism of Action
This peptide functions by cultivating a healthy microbial community on the skin, enhancing the proliferation of beneficial bacteria and improving the skin's innate immune response. It works to strengthen the physical integrity of the skin barrier. Furthermore, in its acetylated form (Acetyl Hexapeptide-49), it targets and regulates the PAR-2 receptor in epidermal keratinocytes, effectively mitigating inflammatory pathways and providing relief from itch in sensitive or sensitized skin.
Research
Clinical Evidence
Medium confidence0.005%
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Peptide stability in aqueous formulations is susceptible to pH and temperature variations. To maintain its efficacy, formulators typically employ strategies such as pH optimization, co-solvency, air exclusion, viscosity enhancement, PEGylation, and the incorporation of polyol excipients.
Safety
Safety Profile
Specific safety assessments by regulatory bodies such as CIR, SCCS, or FDA for HEPTAPEPTIDE-49 are not presently available. However, the CIR Expert Panel generally considers many cosmetic peptides safe for topical application, often at concentrations less than 10 ppm.
Your Skin
Skin Compatibility
Our Assessment
Verdict
HEPTAPEPTIDE-49 is a valuable ingredient, demonstrating significant potential in improving skin microbiome balance, barrier function, and reducing inflammation, making it suitable for a wide range of skin types and concerns, particularly sensitive skin.
Related
Similar Ingredients
Finding similar ingredients…