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Moumoujus

HEPTAPEPTIDE-48.

Valuable / SKIN CONDITIONING

HEPTAPEPTIDE-48 is a specialized heptapeptide designed to enhance the skin's natural repair mechanisms. It actively promotes cell protection and regeneration, leading to improved skin structure and reduced visible signs of aging, particularly wrinkles.

Summary

Skin conditioning Anti-aging Wrinkle reduction Promotes collagen synthesis

Science

Mechanism of Action

This peptide functions as a sophisticated signaling agent, instructing the skin to activate its intrinsic repair pathways. It specifically encourages the regeneration of mature skin cells, thereby bolstering skin structure and visibly diminishing wrinkles. When delivered via solid lipid nanoparticles, a specific heptapeptide (DEETGEF) was shown to stimulate essential cell-protecting enzymes (NQO1, HMOX1, PRDX1), offering crucial defense against UV-induced DNA damage.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

0.014%

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Peptide stability in aqueous solutions is highly influenced by pH, making pH optimization a critical strategy for formulation. Advanced delivery systems such as nanostructured lipid carriers (NLC) or solid lipid nanoparticles (SLN) are recommended to enhance peptide penetration into the skin while providing physical stability and protection for these sensitive active compounds.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

HEPTAPEPTIDE-48 currently lacks a specific safety assessment from the Cosmetic Ingredient Review (CIR) or SCCS. The CIR Expert Panel has issued general guidance suggesting peptides are typically safe for topical application at concentrations below 10 parts per million (ppm), but also notes that combining them with other ingredients may alter safety profiles, and their safety on compromised skin or via injection remains unexplored. It's important to distinguish an FDA statement regarding compounded drugs containing 'semax (heptapeptide)' – which noted potential immunogenicity risks due to aggregation for certain drug routes – as pertaining to drug substances and not specifically to HEPTAPEPTIDE-48 as a cosmetic ingredient.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

HEPTAPEPTIDE-48 is a valuable peptide for anti-aging formulations, supported by clinical evidence demonstrating a reduction in DNA damage and stimulation of protective skin enzymes.

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