Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

HEPTAPEPTIDE-46.

Insufficient Data / SKIN CONDITIONING

Heptapeptide-46 is a specialized signaling peptide designed to mitigate skin hyperreactivity and inflammatory responses. It functions by targeting specific biochemical pathways to calm and soothe sensitive skin, aiming to reduce discomfort and visible signs of irritation.

Summary

anti-inflammatory soothing reduces skin hyperreactivity

Science

Mechanism of Action

This peptide acts as a neurotransmitter inhibitor, effectively reducing the production of UVB-induced inflammatory cytokines, such as IL-8. By limiting the release of pro-inflammatory neuromediators, Heptapeptide-46 contributes to a decrease in overall skin hyperreactivity.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

As with many peptides, Heptapeptide-46 may benefit from pH optimization and the selection of appropriate buffering systems to enhance stability. Strategies such as co-solvency, air exclusion, viscosity enhancement, PEGylation, and the use of polyol excipients can further improve its stability in aqueous solutions. Due to the inherent poor permeability of peptides, advanced delivery systems like liposomes, niosomes, ethosomes, and nanoemulsions are often utilized to maximize its delivery and effectiveness within the skin.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Specific information regarding the Cosmetic Ingredient Review (CIR), SCCS, or FDA status for Heptapeptide-46 is currently unavailable. Regulatory bodies like the CIR often categorize ingredients with insufficient or absent data as 'No Reported Uses' or 'Insufficient Data' until further review can be conducted.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While Heptapeptide-46 demonstrates a promising mechanism for reducing skin hyperreactivity and inflammation, a comprehensive assessment of its efficacy and safety is pending due to the current lack of specific clinical and regulatory review data.

Related

Similar Ingredients

Finding similar ingredients…