Science
Mechanism of Action
This peptide, also known as Acetyl Heptapeptide-4, operates by promoting a healthy microbial community on the skin, increasing beneficial bacteria, and bolstering the skin's innate immune response. It actively strengthens the physical skin barrier by enhancing dermal cell cohesion, functions as a probiotic, and is reported to stimulate collagen and elastin production, which can visibly reduce fine lines and wrinkles while improving moisture retention.
Research
Clinical Evidence
High confidence0.005%
Key findings
- 01 A clinical evaluation at 0.005% concentration for 7 days significantly increased bacterial diversity and microbiome balance. It reduced transepidermal water loss by 27% and decreased exfoliated keratinocyte scale by 18.6%, demonstrating enhanced skin barrier function, hydration, and recovery, particularly beneficial for sensitive skin.
Transparency
Dusting Analysis
Given its demonstrated efficacy at a specific low concentration (0.005%) in clinical studies, Heptapeptide-4 is utilized as a targeted active ingredient rather than a filler, indicating it is not typically 'dusted'.
The Formula
Formulation
Stability
Acetyl Heptapeptide-4 maintains stability for 24 months when stored at -20°C to -15°C in a freezer, protected from light, and in an air-proofed package. It requires storage in a tightly closed container in a dry, cool place, away from direct sunlight. The presence of trifluoroacetic acid (TFA) salts, common from peptide purification, generally enhances its solubility in aqueous solutions.
Safety
Safety Profile
While formal Cosmetic Ingredient Review (CIR) or Scientific Committee on Consumer Safety (SCCS) reports are currently unavailable, Heptapeptide-4 is recognized as a cosmetic ingredient. Assessments from platforms like SkinSAFE classify it as 'Teen SAFE', 'Baby SAFE', 'Eyelid SAFE', 'Irritant Free', 'Fragrance Free', 'Paraben Free', and 'Oil Free', collectively suggesting a very favorable safety profile for topical application.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Heptapeptide-4 is a valuable multi-functional ingredient that precisely targets skin barrier enhancement, microbiome balance, and anti-aging effects for comprehensive skin improvement across all skin types.
Related
Similar Ingredients
Finding similar ingredients…