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Moumoujus

HEPTAPEPTIDE-38.

Valuable / SKIN CONDITIONING

HEPTAPEPTIDE-38, as detailed in available research data (often referenced as Acetyl Hexapeptide-38 or Adifyline®), is a precision biomimetic peptide. It is designed to restore lost skin volume by stimulating adipogenesis within mature fat cells, effectively plumping the skin and visibly diminishing the appearance of age-related fine lines and wrinkles for a smoother complexion.

Summary

skin conditioning anti-aging volumizing plumping improves elasticity reduces wrinkles activates skin repair increases collagen content

Science

Mechanism of Action

This peptide operates by stimulating the expression of peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α). This action enhances the lipid storage capacity in healthy, mature adipocytes, particularly within the white adipose tissue. This specific process, termed adipogenesis, facilitates the restoration of subcutaneous fat volume, especially in areas affected by aging-induced fat loss. The resultant volumetric increase helps to fill wrinkles and fine lines from within, contributing to a plumper, more refined skin texture and improved elasticity. Additionally, it is noted to activate skin repair mechanisms and increase the collagen content within the dermis.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Aqueous solutions are not recommended for storage periods exceeding one day. For the powdered form, optimal stability is maintained by storing at -20°C for up to 3 years, or at -80°C for 1 year when in solvent, with strict avoidance of moisture. The ingredient remains stable under these specified storage conditions.

Conflicts

  • strong acids
  • strong alkalis
  • strong oxidizing agents
  • strong reducing agents

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Evaluations including Human Repeat Insult Patch Tests (HRIPT) demonstrate good skin compatibility, while HET-CAM Tests indicated no ocular irritation. Ames Tests showed no mutagenic or promutagenic effects, and cytotoxicity screenings on human epidermal keratinocytes (HEKa) and 3T3 cells revealed no significant toxic effects. Adverse reactions are considered uncommon; however, a preliminary patch test is recommended prior to extensive use to ensure individual compatibility. The substance is not classified as hazardous and is not listed by IARC, NTP, or OSHA-Ca.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

HEPTAPEPTIDE-38 (Acetyl Hexapeptide-38) is a valuable active for targeted volume restoration and anti-aging, leveraging its unique adipogenesis-stimulating mechanism to visibly reduce wrinkles and enhance skin elasticity, with a favorable safety profile across all skin types.

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