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Moumoujus

HEPTAPEPTIDE-37.

Valuable / SKIN CONDITIONING

HEPTAPEPTIDE-37, known significantly as Acetyl Hexapeptide-37 or Diffuporine, is a sophisticated peptide designed to profoundly enhance cellular hydration. It achieves this by stimulating the production of aquaporin 3, a critical water channel protein, leading to superior moisture distribution, reinforced skin barrier function, and a more resilient complexion.

Summary

Skin conditioning Hydrating Barrier strengthening Collagen boosting Anti-aging Keratinocyte proliferation

Science

Mechanism of Action

This heptapeptide primarily functions by boosting the expression of aquaporin 3 (AQP3) in keratinocytes, facilitating efficient water movement from the deeper epidermal layers to the stratum corneum. Beyond hydration, Acetyl Hexapeptide-37 is noted to support improved skin barrier integrity, stimulate Type I collagen synthesis for structural support, and encourage keratinocyte proliferation, vital for healthy skin renewal.

Research

Clinical Evidence

Medium confidence
Effective range ≥0.001%
Optimal

0.001%

Key findings

  1. 01 A human clinical study involving 20 female volunteers (30-50 years old) demonstrated a significant 131% increase in skin hydration after 56 days of twice-daily application of a cream containing 0.001% (10 µg/ml) Acetyl Hexapeptide-37. This hydrating effect is supported by in vitro findings showing a dose-dependent increase in aquaporin 3 (AQP3) mRNA expression in human keratinocytes at 50 ng/ml and 250 ng/ml concentrations.
  2. 02 Separately, an amorphous heptapeptide (DEETGEF), incorporated at 0.014% into solid lipid nanoparticles, provided significant dose-dependent protection against UV damage and reduced DNA damage by 20% in a clinical suction blister study.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

This peptide, whether as a powder or in solution, requires storage in a sealed container, protected from moisture, to maintain its integrity. Its effectiveness within skincare formulations can be further amplified through the co-application of specialized penetration enhancers.

Synergies

  • Penetration enhancers

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Public safety assessments by major regulatory bodies such as CIR, SCCS, or FDA for HEPTAPEPTIDE-37 or Acetyl Hexapeptide-37 in cosmetic applications are currently unavailable.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

HEPTAPEPTIDE-37 (Acetyl Hexapeptide-37) is a valuable ingredient primarily for its ability to significantly enhance skin hydration and barrier function, alongside anti-aging benefits, though its comprehensive safety profile by major regulatory bodies remains to be formally established.

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References

Sources